faculty

Richard Gardner

gardnerr@uw.edu

University of Washington, 

MCB Director

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Gene Expression, Cell Cycle & Chromosome Biology

Regulation of nuclear functions by ubiquitin and ubiquitin-like modifications

Faculty Contact Information

Building: Health Sciences Building Room: E-421 Box: 357280 Phone: 206-685-0506 http://www.gardnerlab.org/

Lab Information

Location: University of Washington Building: Health Sciences Building Room: E-410 Box: 357280 Phone: 206-616-1976 http://ww.gardnerlab.org/

Accepting Students For:

Rotation, Spring
Rotation, Winter

Publications

The following publications were retrieved from PubMed:

Integrated Proteogenomic Approach for Identifying Degradation Motifs in Eukaryotic Cells.

Geffen Y, Appleboim A, Gardner RG, Ravid T.

Methods Mol Biol. 2018; (1844)121-136

Protein Quality Control Degradation in the Nucleus.

Enam C, Geffen Y, Ravid T, Gardner RG.

Annu Rev Biochem. 2018 Jun 20; (87)725-749

Sex-dependent behavioral impairments in the HdhQ350/+ mouse line.

Cao JK, Detloff PJ, Gardner RG, Stella N.

Behav Brain Res. 2018 Jan 30; (337)34-45

Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity.

Zalewski JK, Mo JH, Heber S, Heroux A, Gardner RG, Hildebrand JD, VanDemark AP.

J Biol Chem. 2016 Dec 2; 49(291)25364-25374

Research Summary

The Gardner lab has a broad scope that focuses on how ubiquitin and ubiquitin-like protein modifiers regulate protein function in the nucleus. Main projects in the Gardner lab converge on elucidating the mechanisms of ubiquitin-mediated misfolded protein degradation in nuclear protein quality control, understanding the functions of ubiquitination in regulating ribosome biogenesis at the level of ribosomal rDNA transcription and ribosome assembly, and uncovering novel roles of protein sumoylation in response to cellular stress.

We welcome new thoughts and new ideas! Come join us!!