faculty

Emily Hatch

ehatch@fredhutch.org

Fred Hutch, 

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Nuclear Envelope Dynamics and Diseases

Faculty Contact Information

Building: Weintraub Room: B2-155 Box: B2-152 Phone: 206-667-5116 Alt Phone: 206-667-5116

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Weintraub Room: B2-135 Box: B2-152 Phone: 206-667-4436 http://research.fhcrc.org/hatch/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Nuclear envelope rupture: little holes, big openings.

Hatch EM

Curr Opin Cell Biol. 2018 Jun; (52)66-72

Y chromothripsis?

Hatch EM

Nat Cell Biol. 2016 Dec 23; 1(19)12-14

Nuclear envelope rupture is induced by actin-based nucleus confinement.

Hatch EM, Hetzer MW.

J Cell Biol. 2016 Oct 10; 1(215)27-36

Linking Micronuclei to Chromosome Fragmentation.

Hatch EM, Hetzer MW.

Cell. 2015 Jun 18; 7(161)1502-4

Chromothripsis.

Hatch EM, Hetzer MW.

Curr Biol. 2015 May 18; 10(25)R397-9

Research Summary

We are at the beginning of redefining the nuclear envelope as a dynamic structure and determining how defects in nuclear envelope stability impact cell function. My lab will use a combination of cell biology, biochemistry, and genomics tools to address the following questions: 1) What are the mechanisms that drive nuclear envelope remodeling and dynamics? and 2) What are the consequences of losing nucleus compartmentalization at the cellular level and how does this contribute to cancer and laminopathy diseases?