Center for Infectious Disease Research,
Cell Signaling & Cell/Environment Interactions
Microbiology, Infection & Immunity
Phosphosignaling in Mycobacterium tuberculosis and chemical proteomics
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Mycobacterium tuberculosis (Mtb) remains the most deadly bacterial pathogen, and rampant drug resistance is requiring renewed efforts to develop new and better therapies. We seek to understand the biology of Mtb phosphosignaling and the biochemical basis of persistence and latency by using microbiology, chemical biology, biochemistry, and structural biology approaches.