faculty

Trisha Davis

tdavis@uw.edu

University of Washington, 

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Biochemical and biophysical analysis of mitosis

Faculty Contact Information

Building: Health Sciences Building Room: J459 Box: 357350 Phone: 206-543-5345 http://depts.washington.edu/biowww/pages/faculty-Davis.shtml

Lab Information

Location: University of Washington Building: Health Sciences Building Room: J457 Box: 357350 Phone: 206-543-5354 http://depts.washington.edu/davislab/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Publications

Human Ska complex and Ndc80 complex interact to form a load-bearing assembly that strengthens kinetochore-microtubule attachments.

Helgeson LA, Zelter A, Riffle M, MacCoss MJ, Asbury CL, Davis TN.

Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(11):2740-2745.

PubMed [journal]
PMID:
29487209
PMCID:
PMC5856539

Identification of Wiskott-Aldrich syndrome protein (WASP) binding sites on the branched actin filament nucleator Arp2/3 complex.

Luan Q, Zelter A, MacCoss MJ, Davis TN, Nolen BJ.

Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(7):E1409-E1418.

PubMed [journal]
PMID:
29386393
PMCID:
PMC5816175

The molecular architecture of the yeast spindle pole body core determined by Bayesian integrative modeling.

Viswanath S, Bonomi M, Kim SJ, Klenchin VA, Taylor KC, Yabut KC, Umbreit NT, Van Epps HA, Meehl J, Jones MH, Russel D, Velazquez-Muriel JA, Winey M, Rayment I, Davis TN, Sali A, Muller EG.

Molecular biology of the cell. 2017; 28(23):3298-3314.

PubMed [journal]
PMID:
28814505
PMCID:
PMC5687031

Direct measurement of the strength of microtubule attachment to yeast centrosomes.

Fong KK, Sarangapani KK, Yusko EC, Riffle M, Llaur├│ A, Graczyk B, Davis TN, Asbury CL.

Molecular biology of the cell. 2017; 28(14):1853-1861.

PubMed [journal]
PMID:
28331072
PMCID:
PMC5541836

The Ndc80 complex bridges two Dam1 complex rings.

Kim JO, Zelter A, Umbreit NT, Bollozos A, Riffle M, Johnson R, MacCoss MJ, Asbury CL, Davis TN.

eLife. 2017; 6.

PubMed [journal]
PMID:
28191870
PMCID:
PMC5354518

Research Summary

How does the cell ensure transmission of an exact complement of chromosomes each cell division? How does this process go awry in cancer cells? These are questions of interest to our lab. We use a variety of techniques from single-molecule biophysical approaches to biochemistry, genetics and microscopy to explore the regulation and action of the cell cycle machinery that ensures fidelity of chromosome segregation.