faculty

David Sherman

david.sherman@cidresearch.org

Center for Infectious Disease Research, 

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Tuberculosis Systems Biology: Virulence And Dormancy

Faculty Contact Information

Building: 307 Westlake Phone: 206-256-7242 https://www.cidresearch.org/labs/sherman

Lab Information

Accepting Students For:

Rotation, Autumn
Rotation, Summer
Rotation, Winter
Permanent

Publications

Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose.

Boot M, van Winden VJC, Sparrius M, van de Weerd R, Speer A, Ummels R, Rustad T, Sherman DR, Bitter W.

PLoS genetics. 2017; 13(12):e1007131.

PubMed [journal]
PMID:
29281637
PMCID:
PMC5760070

Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis.

Moguche AO, Musvosvi M, Penn-Nicholson A, Plumlee CR, Mearns H, Geldenhuys H, Smit E, Abrahams D, Rozot V, Dintwe O, Hoff ST, Kromann I, Ruhwald M, Bang P, Larson RP, Shafiani S, Ma S, Sherman DR, Sette A, Lindestam Arlehamn CS, McKinney DM, Maecker H, Hanekom WA, Hatherill M, Andersen P, Scriba TJ, Urdahl KB.

Cell host & microbe. 2017; 21(6):695-706.e5. NIHMSID: NIHMS881418

PubMed [journal]
PMID:
28618268
PMCID:
PMC5533182

An attenuated Mycobacterium tuberculosis clinical strain with a defect in ESX-1 secretion induces minimal host immune responses and pathology.

Clemmensen HS, Knudsen NPH, Rasmussen EM, Winkler J, Rosenkrands I, Ahmad A, Lillebaek T, Sherman DR, Andersen PL, Aagaard C.

Scientific reports. 2017; 7:46666.

PubMed [journal]
PMID:
28436493
PMCID:
PMC5402389

Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection.

Seshadri C, Sedaghat N, Campo M, Peterson G, Wells RD, Olson GS, Sherman DR, Stein CM, Mayanja-Kizza H, Shojaie A, Boom WH, Hawn TR.

PloS one. 2017; 12(4):e0175844.

PubMed [journal]
PMID:
28414762
PMCID:
PMC5393882

Comprehensive definition of human immunodominant CD8 antigens in tuberculosis.

Lewinsohn DA, Swarbrick GM, Park B, Cansler ME, Null MD, Toren KG, Baseke J, Zalwango S, Mayanja-Kizza H, Malone LL, Nyendak M, Wu G, Guinn K, McWeeney S, Mori T, Chervenak KA, Sherman DR, Boom WH, Lewinsohn DM.

NPJ vaccines. 2017; 2. NIHMSID: NIHMS885826

PubMed [journal]
PMID:
28775896
PMCID:
PMC5538316

Research Summary

With about 30% of the world’s population infected and 1.4 million deaths caused each year, Mycobacterium tuberculosis is the world’s deadliest bacterium. The Sherman laboratory studies the bacterial and host strategies that underpin this success. We use tools of systems biology such as transcriptomics, ChIP-seq and modeling to define the TB gene regulatory network under physiologically relevant conditions, and use the modeling in turn to produce testable hypotheses about novel regulatory circuits, genes and proteins of TB.