faculty

Jonathan Cooper

jcooper@fhcrc.org

Fred Hutch, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Signal transduction by protein phosphorylation and ubiquitination

Faculty Contact Information

Building: Fred Hutch, Weintraub Building Room: A2-105 Box: 358080 Phone: 206-667-4454

Lab Information

Location: Fred Hutch Building: Weintraub Room: A2-111 Phone: 206-667-4465 http://research.fhcrc.org/cooper/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Paracrine Fibroblast Growth Factor Initiates Oncogenic Synergy with Epithelial FGFR/Src Transformation in Prostate Tumor Progression.

Li Q, Ingram L, Kim S, Beharry Z, Cooper JA, Cai H.

Neoplasia (New York, N.Y.). 2018; 20(3):233-243.

PubMed [journal]
PMID:
29444487
PMCID:
PMC5814375

SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.

Pilling C, Cooper JA.

Scientific reports. 2017; 7(1):10838.

PubMed [journal]
PMID:
28883622
PMCID:
PMC5589800

Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.

Jossin Y, Lee M, Klezovitch O, Kon E, Cossard A, Lien WH, Fernandez TE, Cooper JA, Vasioukhin V.

Developmental cell. 2017; 41(5):481-495.e5. NIHMSID: NIHMS874323

PubMed [journal]
PMID:
28552558
PMCID:
PMC5519327

Optogenetic control of the Dab1 signaling pathway.

Wang L, Cooper JA.

Scientific reports. 2017; 7:43760.

PubMed [journal]
PMID:
28272509
PMCID:
PMC5363252

The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells.

Teckchandani A, Cooper JA.

eLife. 2016; 5.

PubMed [journal]
PMID:
27656905
PMCID:
PMC5092051

Research Summary

We investigate the roles of protein phosphorylation and ubiquitination in cell and developmental biology and cancer. We have found that a particular class of phosphotyrosine-directed ubiquitin ligases inhibits cell proliferation and migration. This inhibition is lacking in some cancer cells. We use the tools of molecular, cellular and developmental biology to understand the mechanisms involved and identify the critical substrates. We are particularly interested in how signal inactivation by ubiquitination regulates the spatiotemporal dynamics of signaling and the cellular response.