faculty

Alex Paredez

aparedez@uw.edu

University of Washington, 

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Parasitology and Evolution of the Cytoskeleton

Faculty Contact Information

Building: Hitchcock Hall Room: 407 Box: 351800 Phone: 206-221-9197 http://www.biology.washington.edu/users/aparedez

Lab Information

Accepting Students For:

Permanent

Publications

Hybrid Structured Illumination Expansion Microscopy Reveals Microbial Cytoskeleton Organization.

Halpern AR, Alas GCM, Chozinski TJ, Paredez AR, Vaughan JC.

ACS nano. 2017; 11(12):12677-12686. NIHMSID: NIHMS928262

PubMed [journal]
PMID:
29165993
PMCID:
PMC5752594

14-3-3 Regulates Actin Filament Formation in the Deep-Branching Eukaryote Giardia lamblia.

Krtková J, Xu J, Lalle M, Steele-Ogus M, Alas GCM, Sept D, Paredez AR.

mSphere. 2017; 2(5).

PubMed [journal]
PMID:
28932813
PMCID:
PMC5597967

Myosin-independent cytokinesis in Giardia utilizes flagella to coordinate force generation and direct membrane trafficking.

Hardin WR, Li R, Xu J, Shelton AM, Alas GCM, Minin VN, Paredez AR.

Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(29):E5854-E5863.

PubMed [journal]
PMID:
28679631
PMCID:
PMC5530689

Use of Translation Blocking Morpholinos for Gene Knockdown in Giardia lamblia.

Krtková J, Paredez AR.

Methods in molecular biology (Clifton, N.J.). 2017; 1565:123-140.

PubMed [journal]
PMID:
28364239

Identification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia lamblia.

Hennessey KM, Smith TR, Xu JW, Alas GC, Ojo KK, Merritt EA, Paredez AR.

PLoS neglected tropical diseases. 2016; 10(11):e0005107.

PubMed [journal]
PMID:
27806042
PMCID:
PMC5091913

Research Summary

Giardia lamblia, is an extracellular parasite that uses its cytoskeleton to attach to the host intestine. In addition to being a major parasite, it belongs to a deep branching group of eukaryotes known as the Excavates. Intriguingly, Giardia lacks all canonical actin binding proteins. Still, its actin cytoskeleton performs essential cellular roles and has complex organization that is regulated by a minimalistic Rho GTPase signaling system. We aim to uncover the molecules and mechanisms of cytoskeletal regulation for therapeutic development and to gain evolutionary insight.