faculty

Bonita Brewer

bbrewer@gs.washington.edu

University of Washington, 

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Choreography of eukaryotic DNA replication

Faculty Contact Information

Building: South Foege Room: S041C Box: 355065 Phone: 206-685-4966

Lab Information

Location: University of Washington Building: South Foege Room: S041 Box: 355065 Phone: 206-543-9447 Alt Phone: 206-543-9446 http://fangman-brewer.gs.washington.edu/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Research Summary

DNA replication is undeniably important for life and, as a consequence, cells have evolved mechanisms to monitor replication fidelity and to coordinate completion of replication with other cell cycle events. Using yeast as a model organism, we study how cells choreograph the duplication of their chromosomes, and how defects in initiation of DNA replication contribute to genetic disorders such as the human Meier-Gorlin Syndrome and the mouse chaos3 cancer phenotype. We also are exploring how errors at replication forks contribute to segmental copy number variants that improve fitness.