faculty

Jennifer Lund

jlund@fredhutch.org

Fred Hutch, 

Microbiology, Infection & Immunity

My research program focuses on understanding the basic mechanisms of immunity to viral infections.

Faculty Contact Information

Building: 1100 Eastlake Ave E. Room: E5-155 Box: E5-110 Phone: 206-667-2217 https://www.fredhutch.org/en/labs/profiles/lund-jennifer.html

Lab Information

Location: Fred Hutch Building: 1100 Eastlake Ave E http://research.fhcrc.org/lund/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

A Mouse Model of West Nile Virus Infection.

Graham JB, Swarts JL, Lund JM.

Current protocols in mouse biology. 2017; 7(4):221-235. NIHMSID: NIHMS930922

PubMed [journal]
PMID:
29261232
PMCID:
PMC5777180

Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross.

Graham JB, Swarts JL, Mooney M, Choonoo G, Jeng S, Miller DR, Ferris MT, McWeeney S, Lund JM.

Cell reports. 2017; 21(8):2313-2325. NIHMSID: NIHMS917692

PubMed [journal]
PMID:
29166619
PMCID:
PMC5728448

A Mouse Model of Chronic West Nile Virus Disease.

Graham JB, Swarts JL, Wilkins C, Thomas S, Green R, Sekine A, Voss KM, Ireton RC, Mooney M, Choonoo G, Miller DR, Treuting PM, Pardo Manuel de Villena F, Ferris MT, McWeeney S, Gale M Jr, Lund JM.

PLoS pathogens. 2016; 12(11):e1005996.

PubMed [journal]
PMID:
27806117
PMCID:
PMC5091767

HIV-1-Neutralizing IgA Detected in Genital Secretions of Highly HIV-1-Exposed Seronegative Women on Oral Preexposure Prophylaxis.

Lund JM, Broliden K, Pyra MN, Thomas KK, Donnell D, Irungu E, Muwonge TR, Mugo N, Manohar M, Jansson M, Mackelprang R, Marzinke MA, Baeten JM, Lingappa JR.

Journal of virology. 2016; 90(21):9855-9861.

PubMed [journal]
PMID:
27558421
PMCID:
PMC5068535

Regulatory T cells are essential to promote proper CD4 T-cell priming upon mucosal infection.

Soerens AG, Da Costa A, Lund JM.

Mucosal immunology. 2016; 9(6):1395-1406. NIHMSID: NIHMS760334

PubMed [journal]
PMID:
27007674
PMCID:
PMC5035160

Research Summary

Our focus is on elucidating the basic mechanisms of immunity in the context of virus infection. Specifically, we use mouse models to study T cell responses to genital HSV-2, influenza, and West Nile virus. Additionally, we are investigating the immune correlates of protection from HIV infection using a cohort of exposed seronegative individuals, as well as the potential immune modulatory effects of using pre-exposure prophylaxis in protection from HIV acquisition. Overall, we hope that our studies will lead to improved clinical interventions for virus infections of public health importance.