faculty

Shao-En Ong

shaoen@uw.edu

University of Washington, 

Biophysical and Structural Biology

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Proteogenomic approaches to study gene regulation and cancer

Faculty Contact Information

Building: HSB Box: 357280 Phone: 206-616-6962

Lab Information

Location: University of Washington Building: HSB J-wing Room: J611A-F Box: Box 357280 Phone: 206-685-1882 http://www.quantbiology.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module.

Hsu PL, Li H, Lau HT, Leonen C, Dhall A, Ong SE, Chatterjee C, Zheng N.

Cell. 2018; 174(5):1106-1116.e9. NIHMSID: NIHMS977577

PubMed [journal]
PMID:
30100181
PMCID:
PMC6108940

Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.

Golkowski M, Vidadala RS, Lombard CK, Suh HW, Maly DJ, Ong SE.

Journal of proteome research. 2017; 16(3):1216-1227. NIHMSID: NIHMS914829

PubMed [journal]
PMID:
28102076
PMCID:
PMC5663466

ADP-Ribosylated Peptide Enrichment and Site Identification: The Phosphodiesterase-Based Method.

Daniels CM, Ong SE, Leung AKL.

Methods in molecular biology (Clifton, N.J.). 2017; 1608:79-93. NIHMSID: NIHMS965869

PubMed [journal]
PMID:
28695505
PMCID:
PMC5956525

SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.

Shimizu-Albergine M, Van Yserloo B, Golkowski MG, Ong SE, Beavo JA, Bornfeldt KE.

Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(38):E5685-93.

PubMed [journal]
PMID:
27601673
PMCID:
PMC5035853

ENPP1 processes protein ADP-ribosylation in vitro.

Palazzo L, Daniels CM, Nettleship JE, Rahman N, McPherson RL, Ong SE, Kato K, Nureki O, Leung AK, Ahel I.

The FEBS journal. 2016; 283(18):3371-88. NIHMSID: NIHMS802715

PubMed [journal]
PMID:
27406238
PMCID:
PMC5030157

Research Summary

Our laboratory focuses on developing and applying novel proteomics approaches to measure proteome-wide changes in post-translational modifications and protein abundances whilst studying protein-protein interactions that dynamically regulate cellular processes like growth and proliferation. Another of our major goals is to integrate genomics and proteomics to study dysregulated signaling in cancer. Our team includes experts in chemical biology, genetic analysis, genomics, and proteomics and reflects our passion in research spanning different disciplines.