faculty

Andrea Wills

aewills@uw.edu

University of Washington, 

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Transcriptional regulation of vertebrate regeneration

Faculty Contact Information

Building: HSB J wing Room: J433 Box: 357350 Phone: 543-179

Lab Information

Location: University of Washington Building: HSB J wing Room: J429 Phone: 543-179 http://depts.washington.edu/willslab/wordpress/home-page/

Accepting Students For:

Rotation, Spring
Rotation, Winter
Permanent

Publications

E2a is necessary for Smad2/3-dependent transcription and the direct repression of lefty during gastrulation.

Wills AE, Baker JC.

Developmental cell. 2015; 32(3):345-57. NIHMSID: NIHMS658943

PubMed [journal]
PMID:
25669884
PMCID:
PMC4510980

Developmental enhancers are marked independently of zygotic Nodal signals in Xenopus.

Gupta R, Wills A, Ucar D, Baker J.

Developmental biology. 2014; 395(1):38-49. NIHMSID: NIHMS706990

PubMed [journal]
PMID:
25205067
PMCID:
PMC4517478

Chromatin immunoprecipitation and deep sequencing in Xenopus tropicalis and Xenopus laevis.

Wills AE, Gupta R, Chuong E, Baker JC.

Methods (San Diego, Calif.). 2014; 66(3):410-21. NIHMSID: NIHMS578838

PubMed [journal]
PMID:
24064036
PMCID:
PMC4084882

Interrogating transcriptional regulatory sequences in Tol2-mediated Xenopus transgenics.

Loots GG, Bergmann A, Hum NR, Oldenburg CE, Wills AE, Hu N, Ovcharenko I, Harland RM.

PloS one. 2013; 8(7):e68548.

PubMed [journal]
PMID:
23874664
PMCID:
PMC3713029

RNA sequencing reveals a diverse and dynamic repertoire of the Xenopus tropicalis transcriptome over development.

Tan MH, Au KF, Yablonovitch AL, Wills AE, Chuang J, Baker JC, Wong WH, Li JB.

Genome research. 2013; 23(1):201-16.

PubMed [journal]
PMID:
22960373
PMCID:
PMC3530680

Research Summary

Why is regeneration of adult human tissues so limited, when other vertebrates are readily able to regenerate complex tissues like the spinal cord, cartilage, and limb? Our goal is to define the genetic pathways and epigenetic mechanisms that govern differentiation of different cell types during regeneration and embryogenesis. We employ a combination of genomics, embryology and cell biology using the diploid frog Xenopus tropicalis as a model for regeneration.