faculty

Sergei Doulatov

doulatov@uw.edu

University of Washington, 

Developmental Biology, Stem Cells & Aging

Reprogramming and differentiation of hematopoietic stem cells

Faculty Contact Information

Building: HSB Room: K-236A Box: 357710 Phone: 206-685-9881 http://depts.washington.edu/hemeweb/research/doulatov.htm

Lab Information

Location: University of Washington Building: HSB Room: K-254 Box: 357710 Phone: 206-685-9881 http://depts.washington.edu/hemeweb/research/doulatov.htm

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter

Research Summary

Our blood is constantly replenished through differentiation of hematopoietic stem cells (HSCs). We aim to understand the molecular pathways that regulate stem cell differentiation into different lineages in health and disease states. Since human HSCs are limiting, especially from patients with blood disorders, we use induced pluripotent stem (iPS) cells to model this process. We develop cell reprogramming approaches to instruct various hematopoietic lineage fates starting from iPSCs. Patient iPS cells are used to model blood disorders with the goal of developing novel therapeutics.