faculty

Young Kwon

ykwon7@uw.edu

University of Washington, 

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Genetics, Genomics & Evolution

Mechanisms of growth and wasting

Faculty Contact Information

Building: Health Science Building Room: J441 Box: 357350 Phone: 206-543-6517

Lab Information

Building: Health Science Building Room: J437 Phone: 206-543-1054

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Drosophila melanogaster as a Model of Muscle Degeneration Disorders.

Kreipke RE, Kwon YV, Shcherbata HR, Ruohola-Baker H.

Current topics in developmental biology. 2017; 121:83-109.

PubMed [journal]
PMID:
28057309

Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets.

Vinayagam A, Gibson TE, Lee HJ, Yilmazel B, Roesel C, Hu Y, Kwon Y, Sharma A, Liu YY, Perrimon N, Barabási AL.

Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(18):4976-81.

PubMed [journal]
PMID:
27091990
PMCID:
PMC4983807

Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2.

Kwon Y, Song W, Droujinine IA, Hu Y, Asara JM, Perrimon N.

Developmental cell. 2015; 33(1):36-46. NIHMSID: NIHMS687903

PubMed [journal]
PMID:
25850671
PMCID:
PMC4437243

The Hippo signaling pathway interactome.

Kwon Y, Vinayagam A, Sun X, Dephoure N, Gygi SP, Hong P, Perrimon N.

Science (New York, N.Y.). 2013; 342(6159):737-40. NIHMSID: HHMIMS559534

PubMed [journal]
PMID:
24114784
PMCID:
PMC3951131

PPIRank - an advanced method for ranking protein-protein interations in TAP/MS data.

Sun X, Hong P, Kulkarni M, Kwon Y, Perrimon N.

Proteome science. 2013; 11(Suppl 1):S16.

PubMed [journal]
PMID:
24565074
PMCID:
PMC3908380

Research Summary

Anything that grows eventually decays or undergoes consumption, which is known as atrophy or wasting. Thus, like growth, wasting is a fundamental biological process involved in animal development, homeostasis and aging. My lab studies the molecular, cellular and organismal mechanisms underlying wasting process using our novel fruit fly model of cachexia-like wasting. Cachexia is the wasting syndrome commonly observed in cancer patients. Additionally, we are interested in describing the signaling networks that control organ growth employing functional proteomics and Drosophila genetics.