faculty

Sita Kugel

skugel@fredhutch.org

Fred Hutch, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Gene Expression, Cell Cycle & Chromosome Biology

Epigenetic reprogramming in pancreatic cancer

Faculty Contact Information

Building: Hutchinson Room: C1-163 Box: C1-157 Phone: 206-667-3648 https://www.fredhutch.org/en/labs/profiles/kugel-sita.html

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Hutchinson Room: C1-195 Box: C1-195 Phone: 206-667-2877 https://research.fhcrc.org/kugel/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Research Summary

Although chromatin-remodeling proteins are frequently dysregulated in human cancer, little is known about how they control tumorigenesis. The central theme of our research group is use our panel of genetically engineered mouse models, patient-derived cell lines, xenografts and human tissue samples to study how the dysregulation of chromatin modifying enzymes contributes to pancreatic cancer pathogenesis and, further, whether these pathways present liabilities that could be exploited for cancer therapy.