University of Washington,
Biophysical and Structural Biology
Microbiology, Infection & Immunity
Structural Biology of macromolecular machines
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Macromolecular machines occur ubiquitously in nature where they achieve a broad spectrum of biological functions. Our main research interest is to tackle the structure of macromolecular machines of biomedical interest to understand the mechanisms underlying their functions. We use a multi-disciplinary approach involving cryo-electron microscopy and X-ray crystallography complemented by various biochemical and biophysical techniques to obtain multi-scale data ranging from atom to whole-cell.