University of Washington,
Biophysical and Structural Biology
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Noncoding RNAs and the molecular basis of mammalian nuclear architecture
Faculty Contact Information
Accepting Students For:
My laboratory aims to decipher the molecular mechanisms by which mammalian cells establish and utilize higher-order chromatin structures, with an emphasis on the interplay between noncoding RNAs (ncRNAs) and nuclear architecture. Using our suite of newly developed technologies for probing and manipulating ncRNA function in situ—combined with an array of biochemical, genomic, and chemical biological approaches—we aim to elucidate the mechanisms by which ncRNAs influence nuclear organization at all levels. We believe this will enable new routes towards novel biotechnologies and therapeutics.