Microbiology, Infection & Immunity
Exploring single cell immune dynamics during the development and progression of lung metastasis
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We are working to understand the cellular and molecular dynamics that underlie tumor metastasis (the spread of cancer cells from a primary tumor to distant organs). The main focus of my lab is to understand how tumor-immune cell interactions variably promote or defend against metastasis. We are utilizing cutting edge intravital microscopy to study the dynamic behaviors of immune cells and tumor cells in the living lung. Coupled with scRNAseq we seek to understand how interaction with immune cells such as monocytes, macrophages, and neutrophils dictate metastatic disease outcome.