faculty

Mark Headley

mheadley@fredhutch.org

Fred Hutch, 

Cancer Biology

Microbiology, Infection & Immunity

Exploring single cell immune dynamics during the development and progression of lung metastasis

Faculty Contact Information

Building: Thomas (D) Room: D4-103 Box: D4-100 Phone: 206-667-3619 https://www.fredhutch.org/en/labs/profiles/headley-mark.html

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Thomas (D) Room: D4-245 Box: D4-100 Phone: 206-667-3732 https://www.fredhutch.org/en/labs/profiles/headley-mark.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Research Summary

We are working to understand the cellular and molecular dynamics that underlie tumor metastasis (the spread of cancer cells from a primary tumor to distant organs). The main focus of my lab is to understand how tumor-immune cell interactions variably promote or defend against metastasis. We are utilizing cutting edge intravital microscopy to study the dynamic behaviors of immune cells and tumor cells in the living lung. Coupled with scRNAseq we seek to understand how interaction with immune cells such as monocytes, macrophages, and neutrophils dictate metastatic disease outcome.