faculty

Lucas Sullivan

lucas@fredhutch.org

Fred Hutch, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Understanding metabolic constraints of cell proliferation

Faculty Contact Information

Building: Hutchinson Room: C3-159 Phone: 206-667-7826

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Hutchinson Room: C3-187

Accepting Students For:

Rotation, Spring
Rotation, Winter
Permanent

Publications

Metabolic Frugality Marks Cancer Cells for Immune Targeting.

Sullivan LB.

Cell. 2018; 174(6):1344-1346.

PubMed [journal]
PMID:
30193108

Aspartate is an endogenous metabolic limitation for tumour growth.

Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG.

Nature cell biology. 2018; 20(7):782-788. NIHMSID: NIHMS969303

PubMed [journal]
PMID:
29941931
PMCID:
PMC6051729

Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy.

McLellan CA, Vincent BM, Solis NV, Lancaster AK, Sullivan LB, Hartland CL, Youngsaye W, Filler SG, Whitesell L, Lindquist S.

Nature chemical biology. 2018; 14(2):135-141. NIHMSID: NIHMS916444

PubMed [journal]
PMID:
29227471
PMCID:
PMC5771894

Extracellular vesicles: Taking metabolism on the road.

Sullivan LB.

Nature chemical biology. 2017; 13(9):924-925.

PubMed [journal]
PMID:
28820875

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.

Gui DY, Sullivan LB, Luengo A, Hosios AM, Bush LN, Gitego N, Davidson SM, Freinkman E, Thomas CJ, Vander Heiden MG.

Cell metabolism. 2016; 24(5):716-727. NIHMSID: NIHMS817830

PubMed [journal]
PMID:
27746050
PMCID:
PMC5102768

Research Summary

My lab broadly seeks to understand how metabolism is used to support cell function. One example is to determine the metabolic pathways particularly required for cancer growth and progression, with a goal to identify new targets for cancer therapy. We use mass spectrometry, isotope tracing, metabolomics, and cancer models to understand several themes in metabolism including the role of metabolic pathways in supporting cell proliferation, the network effects of physiologically relevant perturbations to cell metabolism, and discovery of new metabolic products and pathways.