faculty

Dana Miller

dlm16@uw.edu

University of Washington, 

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Molecular genetics of responses to hypoxia and hydrogen sulfide

Faculty Contact Information

Building: HSB J-wing Room: J-587 Box: Box 357350 Phone: 206-685-5025 Alt Phone: 206-685-4497 http://depts.washington.edu/gasgenes/

Lab Information

Location: UW School of Medicine Building: HSB J-wing Room: J-587 Box: 357350 Phone: 206-685-4497 Alt Phone: 2066854497 http://depts.washington.edu/gasgenes/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Caenorhabditis elegans HIF-1 Is Broadly Required for Survival in Hydrogen Sulfide.

Topalidou I, Miller DL.

G3 (Bethesda, Md.). 2017; 7(11):3699-3704.

PubMed [journal]
PMID:
28889102
PMCID:
PMC5677155

Computational Analysis of Lifespan Experiment Reproducibility.

Petrascheck M, Miller DL.

Frontiers in genetics. 2017; 8:92.

PubMed [journal]
PMID:
28713422
PMCID:
PMC5492194

Mitochondrial Sulfide Quinone Oxidoreductase Prevents Activation of the Unfolded Protein Response in Hydrogen Sulfide.

Horsman JW, Miller DL.

The Journal of biological chemistry. 2016; 291(10):5320-5.

PubMed [journal]
PMID:
26677221
PMCID:
PMC4777863

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.

Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M.

Science (New York, N.Y.). 2015; 350(6266):1375-1378. NIHMSID: NIHMS766715

PubMed [journal]
PMID:
26586189
PMCID:
PMC4801033

Tissue-specific autophagy responses to aging and stress in C. elegans.

Chapin HC, Okada M, Merz AJ, Miller DL.

Aging. 2015; 7(6):419-34.

PubMed [journal]
PMID:
26142908
PMCID:
PMC4505168

Research Summary

We study how animals maintain physiological homeostasis in stressful environments. There are three main projects in the lab:
1. To delineate molecular and genetic pathways that mediate adaptive responses to low oxygen (hypoxia). We are particularly interested in how the response to hypoxia impacts cellular proteostasis.
2. To understand hydrogen sulfide signaling pathways and epigenetic responses, and how they impact homeostasis.
3. Interactions between different environmental factors such as nutrients, toxins, hydrogen sulfide, and oxygen.