faculty

Gerry Smith

gsmith@fredhutch.org

Fred Hutch, 

Biophysical and Structural Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Recombination and DNA break repair

Faculty Contact Information

Building: Weintraub Room: A1-155 Box: A1-162 Phone: 206-667-4438 Alt Phone: 206-667-4432 http://sharedresources.fredhutch.org/profile/smith-gerald

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Weintraub Room: A1-149 Box: A1-162 Phone: 206-667-4432 Alt Phone: 206-667-4431 http://research.fhcrc.org/smith/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter

Research Summary

With genetics, enzymology, cytology, deep-sequencing, and single-molecule FRET, we study how broken DNA is repaired and how genetic recombinants arise. We study E. coli’s DNA helicase-nuclease RecBCD and how special DNA sequences (Chi hotspots) control its conformation and activities. In fission yeast, we study how meiotic DNA break hotspots cluster and interact; how repeated pericentric DNA and rDNA are kept silent by heterochromatin and RNAi; and how Holliday junctions are distributed across the genome. Two aims are to understand the origin of certain diseases and to find novel antibiotics.