faculty

Charles Asbury

casbury@uw.edu

University of Washington, 

Biophysical and Structural Biology

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Molecular basis of chromosome segregation during cell division

Faculty Contact Information

Building: HSB G-wing Room: G225 Box: 357290 Phone: 206-543-7808 https://faculty.washington.edu/casbury/index.html

Lab Information

Location: University of Washington Building: HSB G-wing Room: G212 Box: 357290 Phone: 206-543-6968 https://faculty.washington.edu/casbury/index.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

The kinetoplastid kinetochore protein KKT4 is an unconventional microtubule tip-coupling protein.

Llauró A, Hayashi H, Bailey ME, Wilson A, Ludzia P, Asbury CL, Akiyoshi B.

J Cell Biol. 2018 Nov 5; 11(217)3886-3900

Minimizing ATP depletion by oxygen scavengers for single-molecule fluorescence imaging in live cells.

Jung SR, Deng Y, Kushmerick C, Asbury CL, Hille B, Koh DS.

Proc Natl Acad Sci U S A. 2018 Jun 19; 25(115)E5706-E5715

Human Ska complex and Ndc80 complex interact to form a load-bearing assembly that strengthens kinetochore-microtubule attachments.

Helgeson LA, Zelter A, Riffle M, MacCoss MJ, Asbury CL, Davis TN.

Proc Natl Acad Sci U S A. 2018 Mar 13; 11(115)2740-2745

Direct measurement of the strength of microtubule attachment to yeast centrosomes.

Fong KK, Sarangapani KK, Yusko EC, Riffle M, Llauró A, Graczyk B, Davis TN, Asbury CL.

Mol Biol Cell. 2017 Jul 7; 14(28)1853-1861

Research Summary

Our laboratory studies the mitotic spindle, an exquisite molecular machine that organizes and separates duplicated chromosomes during cell division, thereby ensuring equal partitioning of the genetic material. To uncover how this machine operates, we are reconstituting spindle functions using pure components and applying new biophysical tools for manipulating and tracking individual molecules, such as laser trapping and ultrasensitive fluorescence microscopy.