faculty

Steven Hahn

shahn@fredhutch.org

Fred Hutch, 

Biophysical and Structural Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Mechanisms of Eukaryotic Gene Regulation

Faculty Contact Information

Building: A1 Room: 201 Box: A1-162 Phone: 206-667-5261 http://research.fhcrc.org/hahn/en.html

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Weintraub Room: A1-201 Box: A1-162 Phone: 206-667-5263 http://research.fhcrc.org/hahn/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Transcription Activation Domains of the Yeast Factors Met4 and Ino2: Tandem Activation Domains with Properties Similar to the Yeast Gcn4 Activator.

Pacheco D, Warfield L, Brajcich M, Robbins H, Luo J, Ranish J, Hahn S.

Molecular and cellular biology. 2018; 38(10).

PubMed [journal]
PMID:
29507182
PMCID:
PMC5954196

Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex.

Tuttle LM, Pacheco D, Warfield L, Luo J, Ranish J, Hahn S, Klevit RE.

Cell reports. 2018; 22(12):3251-3264. NIHMSID: NIHMS955389

PubMed [journal]
PMID:
29562181
PMCID:
PMC5908246

TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning.

Tomko EJ, Fishburn J, Hahn S, Galburt EA.

Nature structural & molecular biology. 2017; 24(12):1139-1145. NIHMSID: NIHMS928246

PubMed [journal]
PMID:
29106413
PMCID:
PMC5741190

SAGA Is a General Cofactor for RNA Polymerase II Transcription.

Baptista T, Grünberg S, Minoungou N, Koster MJE, Timmers HTM, Hahn S, Devys D, Tora L.

Molecular cell. 2017; 68(1):130-143.e5. NIHMSID: EMS74126

PubMed [journal]
PMID:
28918903
PMCID:
PMC5632562

Transcription of Nearly All Yeast RNA Polymerase II-Transcribed Genes Is Dependent on Transcription Factor TFIID.

Warfield L, Ramachandran S, Baptista T, Devys D, Tora L, Hahn S.

Molecular cell. 2017; 68(1):118-129.e5. NIHMSID: NIHMS901473

PubMed [journal]
PMID:
28918900
PMCID:
PMC5679267

Research Summary

The lab uses a multi disciplinary approach including biochemical, molecular, genomics, and structural methods to examine gene regulatory mechanisms – from detailed molecular interactions to genome-wide functions. Much of our work aims to understand the action of large protein complexes, that are often regulated by dynamic protein-protein interactions. Our three areas of interest are: (i) transcription activators and mechanisms of intrinsically disordered proteins, (ii) the basal Pol II transcription machinery, and (iii) transcription coactivator complexes and their genome-wide roles.