faculty

Mike Crowder

cmc53@uw.edu

University of Washington, 

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Neuroscience

Genetic approaches to hypoxic injury in C. elegans

Faculty Contact Information

Building: SLU North Room: N130 Box: 359724 Phone: 206-897-5987 http://depts.washington.edu/mmcslu/faculty/c-michael-crowder-md-phd/

Lab Information

Location: UW SLU Building: SLU North Building Room: N130 Box: 359724 http://depts.washington.edu/mmcslu/faculty/c-michael-crowder-md-phd/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Ageing and hypoxia cause protein aggregation in mitochondria.

Kaufman DM, Wu X, Scott BA, Itani OA, Van Gilst MR, Bruce JE, Crowder CM.

Cell death and differentiation. 2017; 24(10):1730-1738.

PubMed [journal]
PMID:
28644434
PMCID:
PMC5596417

A screen for protective drugs against delayed hypoxic injury.

Sun CL, Zhang H, Liu M, Wang W, Crowder CM.

PloS one. 2017; 12(4):e0176061.

PubMed [journal]
PMID:
28426808
PMCID:
PMC5398677

Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response.

Mao XR, Kaufman DM, Crowder CM.

Cell death & disease. 2016; 7:e2113.

PubMed [journal]
PMID:
26913604
PMCID:
PMC4849163

Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury.

Kaufman DM, Crowder CM.

Current biology : CB. 2015; 25(16):2171-6. NIHMSID: NIHMS706739

PubMed [journal]
PMID:
26234215
PMCID:
PMC4938157

Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans.

Sun CL, Kim E, Crowder CM.

Cell death and differentiation. 2014; 21(4):557-67.

PubMed [journal]
PMID:
24317200
PMCID:
PMC3950319

Research Summary

Hypoxia and reoxygenation create havoc in cells. This havoc if unrepaired will ultimately lead to cell dysfunction and death in diseases such as myocardial infarction and stroke. We have taken a relatively underutilized approach of performing forward genetic screens in the nematode C. elegans to discover novel mechanisms of hypoxic injury and protection. We have active projects exploring cell non-autonomous mechanisms of hypoxic injury, identification of new genes and new drugs affecting hypoxic injury, and defining the role of mitochondrial protein misfolding in hypoxic injury and ageing.