faculty

Kevin Cheung

kcheung@fredhutch.org

Fred Hutch, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Cellular and molecular basis of tumor cell cluster metastasis

Faculty Contact Information

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Arnold Building Room: M5-A851 http://research.fhcrc.org/cheung/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis.

Greenwood E, Wrenn ED, Cheung KJ.

Developmental cell. 2017; 40(4):328-330.

PubMed [journal]
PMID:
28245919

A collective route to metastasis: Seeding by tumor cell clusters.

Cheung KJ, Ewald AJ.

Science (New York, N.Y.). 2016; 352(6282):167-9.

PubMed [journal]
PMID:
27124449

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters.

Cheung KJ, Padmanaban V, Silvestri V, Schipper K, Cohen JD, Fairchild AN, Gorin MA, Verdone JE, Pienta KJ, Bader JS, Ewald AJ.

Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(7):E854-63.

PubMed [journal]
PMID:
26831077
PMCID:
PMC4763783

3D culture assays of murine mammary branching morphogenesis and epithelial invasion.

Nguyen-Ngoc KV, Shamir ER, Huebner RJ, Beck JN, Cheung KJ, Ewald AJ.

Methods in molecular biology (Clifton, N.J.). 2015; 1189:135-62. NIHMSID: NIHMS755304

PubMed [journal]
PMID:
25245692
PMCID:
PMC4750493

Illuminating breast cancer invasion: diverse roles for cell-cell interactions.

Cheung KJ, Ewald AJ.

Current opinion in cell biology. 2014; 30:99-111. NIHMSID: NIHMS618783

PubMed [journal]
PMID:
25137487
PMCID:
PMC4250974

Research Summary

A grand challenge in cancer biology is the problem of metastasis, the process by which tumor cells seed distant organs. Conventional thinking holds that metastases are seeded by single tumor cells, but recent experimental and clinical studies have unveiled the importance of a collective strategy, in which tumor cells efficiently metastasize as clusters. My laboratory pursues the unique questions that emerge from the clustered state. We are particularly intrigued by mechanisms for cell specialization and cooperation, and their implications for metastasis early detection, prognosis, and therapy.