faculty

Patrick Paddison

paddison@fredhutch.org

Fred Hutch, 

Cancer Biology

Developmental Biology, Stem Cells & Aging

Functional genomics of stem cell and cancer cell biology

Faculty Contact Information

Building: Hutchinson Room: C3-205 Box: C3-168 Phone: 206-667-4312 Alt Phone: 206-667-4474 http://research.fhcrc.org/paddison/en.html

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Hutchinson Room: C3-187 Box: C3-168 Phone: 206-667-4108 Alt Phone: 206-667-4474 http://research.fhcrc.org/paddison/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.

Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE.

Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(21):5462-5467.

PubMed [journal]
PMID:
29735700

Sensitivity to BUB1B Inhibition Defines an Alternative Classification of Glioblastoma.

Lee E, Pain M, Wang H, Herman JA, Toledo CM, DeLuca JG, Yong RL, Paddison P, Zhu J.

Cancer research. 2017; 77(20):5518-5529. NIHMSID: NIHMS902923

PubMed [journal]
PMID:
28855212
PMCID:
PMC5645262

ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5.

Ding Y, Herman JA, Toledo CM, Lang JM, Corrin P, Girard EJ, Basom R, Delrow JJ, Olson JM, Paddison PJ.

Oncotarget. 2017; 8(30):48545-48562.

PubMed [journal]
PMID:
28596487
PMCID:
PMC5564707

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.

Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, Horbinski CM, Zuber J, Scacheri PC, Bernstein BE, Tesar PJ, Rich JN.

Nature. 2017; 547(7663):355-359. NIHMSID: NIHMS882515

PubMed [journal]
PMID:
28678782
PMCID:
PMC5896562

Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy.

Pollak J, Rai KG, Funk CC, Arora S, Lee E, Zhu J, Price ND, Paddison PJ, Ramirez JM, Rostomily RC.

PloS one. 2017; 12(3):e0172884.

PubMed [journal]
PMID:
28264064
PMCID:
PMC5338779

Research Summary

The Paddison Lab uses functional genomics to probe the underlying biology of mammalian stem and progenitor cells. Our primary goal is to define the biological units of self-renewal, expansion, and lineage commitment in model stem cell systems, including: embryonic stem cells, hematopoietic stem cells, neural progenitor cells, and brain tumor initiating cells (i.e., brain tumor stem cells). We are particularly interested in the understanding the molecular mechanisms that allow stem cells to maintain their unique identity and developmental potential.