faculty

Justin Taylor

jtaylor3@fredhutch.org

Fred Hutch, 

Microbiology, Infection & Immunity

Understanding Protective B cell responses

Faculty Contact Information

Building: 1100 Eastlake Room: E5-152 Box: E5-110 Phone: 206-667-7794 Alt Phone: 206-667-7794

Lab Information

Location: Fred Hutch Building: Eastlake Room: E5-320 Box: E5-110 Phone: 206-667-7794 http://research.fhcrc.org/taylor/en.html

Accepting Students For:

Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Decrease in Numbers of Naive and Resting B Cells in HIV-Infected Kenyan Adults Leads to a Proportional Increase in Total and Plasmodium falciparum-Specific Atypical Memory B Cells.

Frosch AE, Odumade OA, Taylor JJ, Ireland K, Ayodo G, Ondigo B, Narum DL, Vulule J, John CC.

Journal of immunology (Baltimore, Md. : 1950). 2017; 198(12):4629-4638.

PubMed [journal]
PMID:
28526680
PMCID:
PMC5458331

Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.

Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinov T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, Fife BT.

Nature communications. 2016; 7:11804.

PubMed [journal]
PMID:
27292946
PMCID:
PMC4909947

General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice.

Hamilton JA, Li J, Wu Q, Yang P, Luo B, Li H, Bradley JE, Taylor JJ, Randall TD, Mountz JD, Hsu HC.

Journal of immunology (Baltimore, Md. : 1950). 2015; 194(10):5022-34. NIHMSID: NIHMS674165

PubMed [journal]
PMID:
25888644
PMCID:
PMC4417409

IL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism.

Fairfax KC, Everts B, Amiel E, Smith AM, Schramm G, Haas H, Randolph GJ, Taylor JJ, Pearce EJ.

Journal of immunology (Baltimore, Md. : 1950). 2015; 194(7):2999-3010. NIHMSID: NIHMS658566

PubMed [journal]
PMID:
25712216
PMCID:
PMC4495582

The transcription factor KLF2 restrains CD4⁺ T follicular helper cell differentiation.

Lee JY, Skon CN, Lee YJ, Oh S, Taylor JJ, Malhotra D, Jenkins MK, Rosenfeld MG, Hogquist KA, Jameson SC.

Immunity. 2015; 42(2):252-264. NIHMSID: NIHMS662368

PubMed [journal]
PMID:
25692701
PMCID:
PMC4409658

Research Summary

Most vaccines provide protection by inducing the production of antibodies that can bind to a pathogen and block infection. Unfortunately, there are many dangerous viruses in which the development of a vaccine has been elusive despite decades of intense research. These failures highlight gaps in knowledge about the type of cell that can produce antibodies, the B cell. The Taylor lab aims to inform vaccine design by gaining a deeper understanding about the mechanisms limiting the generation of a protective B cell response.