faculty

Adam Geballe

ageballe@fredhutch.org

Fred Hutch, 

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Virus host cell conflicts; control of protein synthesis

Faculty Contact Information

Building: C - Hutchinson Room: C2-155 Box: C2-023 or UW BOX 358080 Phone: 206-667-5122

Lab Information

Location: Fred Huth Building: C2 - Hutchinson Room: C2-135 Phone: 206-667-5199

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter

Publications

Adaptation by copy number variation in monopartite viruses.

Bayer A, Brennan G, Geballe AP.

Current opinion in virology. 2018; 33:7-12.

PubMed [journal]
PMID:
30015083

Inhibition of vaccinia virus replication by nitazoxanide.

Hickson SE, Margineantu D, Hockenbery DM, Simon JA, Geballe AP.

Virology. 2018; 518:398-405. NIHMSID: NIHMS957708

PubMed [journal]
PMID:
29625403
PMCID:
PMC5929478

Antagonism of the Protein Kinase R Pathway in Human Cells by Rhesus Cytomegalovirus.

Child SJ, Hickson SE, Bayer A, Malouli D, Früh K, Geballe AP.

Journal of virology. 2018; 92(6).

PubMed [journal]
PMID:
29263260
PMCID:
PMC5827409

A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists.

Carpentier KS, Esparo NM, Child SJ, Geballe AP.

PLoS pathogens. 2016; 12(10):e1005966.

PubMed [journal]
PMID:
27780231
PMCID:
PMC5079575

The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.

Gray EE, Winship D, Snyder JM, Child SJ, Geballe AP, Stetson DB.

Immunity. 2016; 45(2):255-66. NIHMSID: NIHMS808505

PubMed [journal]
PMID:
27496731
PMCID:
PMC4988931

Research Summary

Research in the Geballe lab focuses on identifying the factors, dissecting the mechanisms, and understanding the evolutionary pathways used by viruses, such as cytomegaloviruses, poxviruses, and flaviviruses to enable viral replication in the face of host defenses.