faculty

Maitreya Dunham

maitreya@uw.edu

University of Washington, 

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Genome evolution and copy number variation in yeasts

Faculty Contact Information

Building: Foege Room: S403B Box: 355065 Phone: 206-543-2338 http://dunham.gs.washington.edu/

Lab Information

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Publications

Identification of a novel interspecific hybrid yeast from a metagenomic spontaneously inoculated beer sample using Hi-C.

Smukowski Heil C, Burton JN, Liachko I, Friedrich A, Hanson NA, Morris CL, Schacherer J, Shendure J, Thomas JH, Dunham MJ.

Yeast (Chichester, England). 2018; 35(1):71-84. NIHMSID: NIHMS905334

PubMed [journal]
PMID:
28892574
PMCID:
PMC5771821

Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae.

McDonald MG, Ray S, Amorosi CJ, Sitko KA, Kowalski JP, Paco L, Nath A, Gallis B, Totah RA, Dunham MJ, Fowler DM, Rettie AE.

Drug metabolism and disposition: the biological fate of chemicals. 2017; 45(12):1364-1371.

PubMed [journal]
PMID:
29018033
PMCID:
PMC5697098

Variant Interpretation: Functional Assays to the Rescue.

Starita LM, Ahituv N, Dunham MJ, Kitzman JO, Roth FP, Seelig G, Shendure J, Fowler DM.

American journal of human genetics. 2017; 101(3):315-325.

PubMed [journal]
PMID:
28886340
PMCID:
PMC5590843

A multiplex culture system for the long-term growth of fission yeast cells.

Callens C, Coelho NC, Miller AW, Sananes MRD, Dunham MJ, Denoual M, Coudreuse D.

Yeast (Chichester, England). 2017; 34(8):343-355. NIHMSID: NIHMS870507

PubMed [journal]
PMID:
28426144
PMCID:
PMC5542872

Chemostat Culture for Yeast Physiology and Experimental Evolution.

Dunham MJ, Kerr EO, Miller AW, Payen C.

Cold Spring Harbor protocols. 2017; 2017(7):pdb.top077610.

PubMed [journal]
PMID:
28679718

Research Summary

The Dunham Lab studies genome evolution and copy number variation in yeast using experimental evolution and comparative genomics approaches. Current projects include understanding the costs and benefits of aneuploidy, evolving hybrid yeasts, building new instruments for continuous culture, comparative functional genomics of centromeres and replication origins, and developing high throughput methods for measuring the impact of genetic variation in yeast and humans.