faculty

Jason Smith

jgsmith2@uw.edu

University of Washington, 

Developmental Biology, Stem Cells & Aging

Microbiology, Infection & Immunity

Host/Pathogen Interactions in the Intestine

Faculty Contact Information

Building: South Lake Union Building F Room: F571 Box: 358070 Phone: 206-685-6144 https://microbiology.washington.edu/users/jason-g-smith

Lab Information

Location: University of Washington Building: South Lake Union Building F Room: F560 Box: 358070 Phone: 206-616-5649 http://faculty.washington.edu/jgsmith2/Welcome.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Structure and N-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre.

Singh AK, Nguyen TH, Vidovszky MZ, Harrach B, Benkő M, Kirwan A, Joshi L, Kilcoyne M, Berbis MÁ, Cañada FJ, Jiménez-Barbero J, Menéndez M, Wilson SS, Bromme BA, Smith JG, van Raaij MJ.

The Journal of general virology. 2018; 99(11):1494-1508.

PubMed [journal]
PMID:
30277856

Obstructive Lymphangitis Precedes Colitis in Murine Norovirus-Infected Stat1-Deficient Mice.

Seamons A, Treuting PM, Meeker S, Hsu C, Paik J, Brabb T, Escobar SS, Alexander JS, Ericsson AC, Smith JG, Maggio-Price L.

The American journal of pathology. 2018; 188(7):1536-1554.

PubMed [journal]
PMID:
29753791
PMCID:
PMC6109697

Paneth Cells during Viral Infection and Pathogenesis.

Holly MK, Smith JG.

Viruses. 2018; 10(5).

PubMed [journal]
PMID:
29701691
PMCID:
PMC5977218

Adenovirus infection of human enteroids reveals interferon sensitivity and preferential infection of goblet cells.

Holly MK, Smith JG.

Journal of virology. 2018;

PubMed [journal]
PMID:
29467318
PMCID:
PMC5899204

Defensins in Viral Infection and Pathogenesis.

Holly MK, Diaz K, Smith JG.

Annual review of virology. 2017; 4(1):369-391.

PubMed [journal]
PMID:
28715972

Research Summary

The Smith lab is primarily focused on host/pathogen interactions at mucosal surfaces. We have recently adopted a new 3D intestinal enteroid culture methodology that enables us to study the gut epithelium under more physiologic conditions. We are using this system to examine sensing of viruses and bacteria by host cells and to study the development, cell biology, and secretion mechanisms of intestinal epithelial cells. A major secreted host protein that we study is antimicrobial peptides called defensins, and we are interested in their role in viral infection and pathogenesis.