faculty

Daniel Promislow

promislo@uw.edu

University of Washington, 

Developmental Biology, Stem Cells & Aging

Genetics, Genomics & Evolution

Neuroscience

Evolutionary and quantitative genetics of aging and reproduction

Faculty Contact Information

Building: K-wing, Magnuson Health Sciences Center Room: K-076 Box: 357705 Phone: 206-616-6994 http://www.promislowlab.org/

Lab Information

Location: University of Washington Building: K-Wing, Magnuson Health Sciences Center Room: K-088 Box: 357705 Phone: 206-616-5060 http://www.promislowlab.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Recent Advances in the Systems Biology of Aging.

McCormick MA, Promislow DEL.

Antioxidants & redox signaling. 2018; 29(10):973-984.

PubMed [journal]
PMID:
29020802
PMCID:
PMC6104255

Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.

Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM.

Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(38):9586-9591.

PubMed [journal]
PMID:
30185560
PMCID:
PMC6156608

The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue.

Derous D, Mitchell SE, Green CL, Wang Y, Han JDJ, Chen L, Promislow DEL, Lusseau D, Douglas A, Speakman JR.

The journals of gerontology. Series A, Biological sciences and medical sciences. 2018; 73(3):279-288.

PubMed [journal]
PMID:
28575190
PMCID:
PMC5861923

Tissue-specific insulin signaling mediates female sexual attractiveness.

Fedina TY, Arbuthnott D, Rundle HD, Promislow DEL, Pletcher SD.

PLoS genetics. 2017; 13(8):e1006935.

PubMed [journal]
PMID:
28817572
PMCID:
PMC5560536

The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome.

Derous D, Mitchell SE, Wang L, Green CL, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Speakman JR.

Aging. 2017; 9(7):1770-1824.

PubMed [journal]
PMID:
28768896
PMCID:
PMC5559174

Research Summary

My research is focused on trying to understand the basic forces that shape fitness traits in natural populations. I also use a systems biology approach to probe the mechanisms by which genotypes shape phenotypes. The evolution of aging serves as a conceptual focus for much of our work, but the lab is equally marked by the diversity of interests of the students and post-docs, including neurodegenerative disease, sexual selection, and epigenetics. While most lab studies are on flies, I also run a large national long-term study on the systems biology of aging in dogs.