faculty

Naeha Subramanian

naeha.subramanian@systemsbiology.org

Institute for Systems Biology, 

Cancer Biology

Microbiology, Infection & Immunity

Regulation of Intracellular Innate Immunity

Faculty Contact Information

Lab Information

Location: Institute for Systems Biology https://www.systemsbiology.org/people/faculty/subramanian-lab/

Accepting Students For:

Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

NAGging Hexokinase PEPs up NLRP3.

Hampton H, Hutcheon C, Subramanian N.

Cell host & microbe. 2016; 20(2):130-2.

PubMed [journal]
PMID:
27512900

Encyclopedia of Cell Biology

Hutcheon C, Paulvannan P, Subramanian N.

1st ed. Bradshaw RA, Stahl PD, editors. United States of America: Elsevier; 2016. Cytoplasmic sensing in innate immunity; p.710-726. 3008p.

My Bibliography [book]

AIMing 2 Curtail Cancer.

Rommereim LM, Subramanian N.

Cell. 2015; 162(1):18-20.

PubMed [journal]
PMID:
26140588

Network representations of immune system complexity.

Subramanian N, Torabi-Parizi P, Gottschalk RA, Germain RN, Dutta B.

Wiley interdisciplinary reviews. Systems biology and medicine. 2015; 7(1):13-38. NIHMSID: NIHMS654902

PubMed [journal]
PMID:
25625853
PMCID:
PMC4339634

The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation.

Subramanian N, Natarajan K, Clatworthy MR, Wang Z, Germain RN.

Cell. 2013; 153(2):348-61. NIHMSID: NIHMS454353

PubMed [journal]
PMID:
23582325
PMCID:
PMC3632354

Research Summary

We study innate immune responses mediated by a class of intracellular sensors of pathogens and danger called the NOD-like receptors (NLRs) and their role in immune disease. A key aspect is using unbiased systems biology approaches for combining information from multiple levels such as genes, proteins and whole cells to identify NLR signaling pathways and their regulation. Another major focus is on investigating the activation of inflammasomes, which are signaling complexes formed by some NLRs, and the role of sub-cellular structures such as mitochondria in regulation of inflammasome function.