faculty

David MacPherson

dmacpher@fhcrc.org

Fred Hutch, 

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Cancer Genetics, Mouse Models

Faculty Contact Information

Lab Information

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Publications

Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.

Jia D, Augert A, Kim DW, Eastwood E, Wu N, Ibrahim AH, Kim KB, Dunn CT, Pillai SPS, Gazdar AF, Bolouri H, Park KS, MacPherson D.

Cancer discovery. 2018;

PubMed [journal]
PMID:
30181244

Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance).

Augert A, Zhang Q, Bates B, Cui M, Wang X, Wildey G, Dowlati A, MacPherson D.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2017; 12(4):704-713. NIHMSID: NIHMS838312

PubMed [journal]
PMID:
28007623
PMCID:
PMC5669801

A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence.

Wu N, Jia D, Bates B, Basom R, Eberhart CG, MacPherson D.

The Journal of clinical investigation. 2017; 127(3):888-898.

PubMed [journal]
PMID:
28165337
PMCID:
PMC5330763

Genomic landscape of retinoblastoma in Rb-/- p130-/- mice resembles human retinoblastoma.

Kooi IE, van Mil SE, MacPherson D, Mol BM, Moll AC, Meijers-Heijboer H, Kaspers GJ, Cloos J, Te Riele H, Dorsman JC.

Genes, chromosomes & cancer. 2017; 56(3):231-242.

PubMed [journal]
PMID:
27750399

Lung Cancer Subtypes Generate Unique Immune Responses.

Busch SE, Hanke ML, Kargl J, Metz HE, MacPherson D, Houghton AM.

Journal of immunology (Baltimore, Md. : 1950). 2016; 197(11):4493-4503. NIHMSID: NIHMS821782

PubMed [journal]
PMID:
27799309
PMCID:
PMC5116260

Research Summary

Our lab is focused on understanding mechanisms through which cancer-mutated genes drive tumorigenesis. We study small cell lung cancer, a highly aggressive and metastatic neuroendocrine tumor type. We perform genomic analyses to identify gene mutations that may contribute to tumor initiation, progression, and metastasis. We make extensive use of genetically engineered mouse models, as well as patient derived xenograft (PDX models) to understand cancer mutated genes and to develop and test novel therapeutic approaches.