faculty

Barry Gumbiner

gumbiner@uw.edu

Seattle Childrens Research Institute, 

Biophysical and Structural Biology

Cancer Biology (Area Director)

Cell Signaling & Cell/Environment Interactions

Cell Adhesion in Morphogenesis and Disease

Faculty Contact Information

Building: Jack MacDonald Bldg Room: JMB 523 Box: JMB-5 Phone: 206-884-5116 http://www.seattlechildrens.org/research/developmental-biology-regenerative-medicine/gumbiner-lab/

Lab Information

Location: Seattle Childrens Research Institute Building: Jack MacDonald Building Room: JMB 523 Box: JMB-5 http://www.seattlechildrens.org/research/developmental-biology-regenerative-medicine/gumbiner-lab/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

E-cadherin in contact inhibition and cancer.

Mendonsa AM, Na TY, Gumbiner BM.

Oncogene. 2018 Aug; 35(37)4769-4780

Roles for E-cadherin cell surface regulation in cancer.

Petrova YI, Schecterson L, Gumbiner BM.

Mol Biol Cell. 2016 Nov 1; 21(27)3233-3244

Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.

Kim NG, Gumbiner BM.

J Cell Biol. 2015 Aug 3; 3(210)503-15

Research Summary

We are interested in tissue architecture and morphogenesis, which is important for the development of embryos and organs, the maintenance and regeneration of tissues, and the control of diseases, such as cancer and inflammation. We study how cadherin adhesive function at the cell surface is regulated to control cell-cell junctions during morphogenesis, tumor metastasis, and epithelial and endothelial barrier function and inflammation. We also study how cell contacts and cadherins signal into the cell to control growth and differentiation through the Wnt-ß-catenin and Hippo signaling pathways.