faculty

Roland Strong

rstrong@fhcrc.org

Fred Hutch, 

Biophysical and Structural Biology (Area Director)

Microbiology, Infection & Immunity

Structural Molecular Immunology, Vaccinology, & Translational Biophysics

Faculty Contact Information

Building: Weintraub Room: B3-163 Box: 358080 Phone: 206-667-5587

Lab Information

Location: Fred Hutch Building: Weintraub Room: B3-183 Box: 358080 Phone: 667-558 http://research.fhcrc.org/strong/en.html

Publications

Patient HLA Germline Variation and Transplant Survivorship.

Petersdorf EW, Stevenson P, Malkki M, Strong RK, Spellman SR, Haagenson MD, Horowitz MM, Gooley T, Wang T.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018; 36(24):2524-2531.

PubMed [journal]
PMID:
29902106
PMCID:
PMC6097831

Publisher Correction: Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets.

Crook ZR, Sevilla GP, Friend D, Brusniak MY, Bandaranayake AD, Clarke M, Gewe M, Mhyre AJ, Baker D, Strong RK, Bradley P, Olson JM.

Nature communications. 2018; 9(1):1072.

PubMed [journal]
PMID:
29523778
PMCID:
PMC5844863

Screening, large-scale production and structure-based classification of cystine-dense peptides.

Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK.

Nature structural & molecular biology. 2018; 25(3):270-278. NIHMSID: NIHMS937122

PubMed [journal]
PMID:
29483648
PMCID:
PMC5840021

Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets.

Crook ZR, Sevilla GP, Friend D, Brusniak MY, Bandaranayake AD, Clarke M, Gewe M, Mhyre AJ, Baker D, Strong RK, Bradley P, Olson JM.

Nature communications. 2017; 8(1):2244.

PubMed [journal]
PMID:
29269835
PMCID:
PMC5740061

Chelation and stabilization of berkelium in oxidation state +IV.

Deblonde GJ, Sturzbecher-Hoehne M, Rupert PB, An DD, Illy MC, Ralston CY, Brabec J, de Jong WA, Strong RK, Abergel RJ.

Nature chemistry. 2017; 9(9):843-849.

PubMed [journal]
PMID:
28837177

Research Summary

Our research focus is molecular immunology and vaccinology, studying how recognition mechanisms increase the breadth and utility of innate and adaptive immunoreceptors, and can be exploited in engineering therapeutics and diagnostics, and immunogens that elicit targeted responses. We use biophysical approaches to study NK, T, and B cell receptors, understand immunorecognition of siderophores, further prophylactic and therapeutic vaccine development, and engineer targeted immunotheranostics. Key approaches include macromolecular structure determination by x-ray crystallography and surface plasm