faculty

Suzanne Hoppins

shoppins@uw.edu

University of Washington, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Mechanism and regulation of mitochondrial fusion.

Faculty Contact Information

Building: Health Sciences Building Room: J383 Box: Box 357350 Phone: 206-616-7565 http://blogs.uw.edu/shoppins/

Lab Information

Location: University of Washington Building: Health Sciences Building Room: J379 Box: Box 357350 Phone: 206-616-8529 http://blogs.uw.edu/shoppins/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Aberrant Drp1-mediated mitochondrial division presents in humans with variable outcomes.

Whitley B, Lam C, Cui H, Haude K, Bai R, Escobar L, Hamilton A, Brady L, Tarnopolsky MA, Dengle L, Picker J, Lincoln S, Lackner LL, Glass IA, Hoppins S.

Hum Mol Genet. 2018 Aug 2;

The regulation of mitochondrial dynamics.

Hoppins S

Curr Opin Cell Biol. 2014 Aug; (29)46-52

Uniform nomenclature for the mitochondrial contact site and cristae organizing system.

Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J.

J Cell Biol. 2014 Mar 31; 7(204)1083-6

Cell Biology. Mitochondrial dynamics and apoptosis--the ER connection.

Hoppins S, Nunnari J.

Science. 2012 Aug 31; 6098(337)1052-4

Research Summary

Mitochondrial membrane fusion is mechanistically unique and poorly understood. Mitochondrial dynamics are essential for mitochondrial function and are also integrated with other processes such as cell cycle progression, cellular immune responses, and apoptotic cell death. Impaired mitochondrial fusion leads to general mitochondrial dysfunction, which has been implicated in several significant public health burdens including Alzheimer’s disease and cancer.