faculty

Valeri Vasioukhin

vvasiouk@fhcrc.org

Fred Hutch, 

Cancer Biology (Area Director)

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

cell polarity and cell-cell adhesion in normal development and cancer

Faculty Contact Information

Building: C3 Room: C3-155 Box: C3-168 Phone: 206-667-1710 https://www.fredhutch.org/en/labs/profiles/vasioukhin-valeri.html

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: C3 Room: C3-175 Box: C3-168 Phone: 206-667-1543 http://research.fhcrc.org/vasioukhin/en.html

Accepting Students For:

Rotation, Spring
Rotation, Winter
Permanent

Publications

Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.

Jossin Y, Lee M, Klezovitch O, Kon E, Cossard A, Lien WH, Fernandez TE, Cooper JA, Vasioukhin V.

Developmental cell. 2017; 41(5):481-495.e5. NIHMSID: NIHMS874323

PubMed [journal]
PMID:
28552558
PMCID:
PMC5519327

Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells.

Beattie R, Postiglione MP, Burnett LE, Laukoter S, Streicher C, Pauler FM, Xiao G, Klezovitch O, Vasioukhin V, Ghashghaei TH, Hippenmeyer S.

Neuron. 2017; 94(3):517-533.e3.

PubMed [journal]
PMID:
28472654

ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development.

Sreenath TL, Macalindong SS, Mikhalkevich N, Sharad S, Mohamed A, Young D, Borbiev T, Xavier C, Gupta R, Jamal M, Babcock K, Tan SH, Nevalainen MT, Dobi A, Petrovics G, Sesterhenn IA, Rosner IL, Bieberich CJ, Nelson P, Vasioukhin V, Srivastava S.

Scientific reports. 2017; 7(1):1109.

PubMed [journal]
PMID:
28439080
PMCID:
PMC5430720

DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen CC, Ratkovic S, Klezovitch O, Attisano L, McNeill H, Emili A, Vasioukhin V.

Genes & development. 2016; 30(24):2696-2709.

PubMed [journal]
PMID:
28087714
PMCID:
PMC5238729

αE-catenin inhibits a Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway.

Li P, Silvis MR, Honaker Y, Lien WH, Arron ST, Vasioukhin V.

Genes & development. 2016; 30(7):798-811.

PubMed [journal]
PMID:
27013234
PMCID:
PMC4826396

Research Summary

Three major research directions:
1. Cell polarity mechanisms responsible for asymmetric cell divisions that help to ensure the maintenance of pluripotent stem cells and normal differentiation.
2. Cell-cell adhesion structures as biosensors of cellular microenvironment involved in regulation of cell proliferation, differentiation and programmed cell death?
3. Molecular mechanisms and novel therapeutic approaches in human prostate cancer.