faculty

Sue Biggins

sbiggins@fredhutch.org

Fred Hutch, 

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Chromosome Segregation

Faculty Contact Information

Building: Weintraub Room: A2-155 Box: A2-168 Phone: 206-667-1351 http://research.fhcrc.org/biggins/en.html

Lab Information

Location: Fred Hutch Building: Weintraub Room: A2-149 Box: A2-168 Phone: 206-667-5766 http://research.fhcrc.org/biggins/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

A Kinesin-5, Cin8, Recruits Protein Phosphatase 1 to Kinetochores and Regulates Chromosome Segregation.

Suzuki A, Gupta A, Long SK, Evans R, Badger BL, Salmon ED, Biggins S, Bloom K.

Curr Biol. 2018 Sep 10; 17(28)2697-2704.e3

Design principles of a microtubule polymerase.

Geyer EA, Miller MP, Brautigam CA, Biggins S, Rice LM.

Elife. 2018 Jun 13; (7)

Purification of kinetochores from the budding yeast Saccharomyces cerevisiae.

Gupta A, Evans RK, Koch LB, Littleton AJ, Biggins S.

Methods Cell Biol. 2018; (144)349-370

Research Summary

Aneuploidy is the most common chromosome abnormality in cancers and is the cause of birth defects and other diseases. We therefore study the controls over cell division and chromosome segregation that ensure accurate self-renewal, proliferation and development. We take an interdisciplinary approach that combines biophysical, cell biological, biochemical and genetic techniques to tackle these questions using yeast and human cells as model systems.