faculty

Nina Salama

nsalama@fredhutch.org

Fred Hutch, 

MCB Director

Cancer Biology

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Pathogenesis of Helicobacter pylori stomach infection

Faculty Contact Information

Building: Hutchinson Room: C3-159 Box: 358080 Phone: 206-667-1540 Alt Phone: 206-667-1545 http://research.fhcrc.org/salama

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Hutchinson Room: C3-135 Box: C3-168 Phone: 206-667-1545 http://research.fhcrc.org/salama

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Droplet Digital PCR-Based Detection of Clarithromycin Resistance in Helicobacter pylori Isolates Reveals Frequent Heteroresistance.

Sun L, Talarico S, Yao L, He L, Self S, You Y, Zhang H, Zhang Y, Guo Y, Liu G, Salama NR, Zhang J.

Journal of clinical microbiology. 2018; 56(9).

PubMed [journal]
PMID:
29925646
PMCID:
PMC6113488

The Helicobacter pylori cell shape promoting protein Csd5 interacts with the cell wall, MurF, and the bacterial cytoskeleton.

Blair KM, Mears KS, Taylor JA, Fero J, Jones LA, Gafken PR, Whitney JC, Salama NR.

Molecular microbiology. 2018; 110(1):114-127.

PubMed [journal]
PMID:
30039535

High prevalence of Helicobacter pylori clarithromycin resistance mutations among Seattle patients measured by droplet digital PCR.

Talarico S, Korson AS, Leverich CK, Park S, Jalikis FG, Upton MP, Broussard E, Salama NR.

Helicobacter. 2018; 23(2):e12472. NIHMSID: NIHMS940073

PubMed [journal]
PMID:
29480566
PMCID:
PMC5867253

TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection.

Gall A, Gaudet RG, Gray-Owen SD, Salama NR.

mBio. 2017; 8(4).

PubMed [journal]
PMID:
28811347
PMCID:
PMC5559637

Correction: The O-Antigen Flippase Wzk Can Substitute for MurJ in Peptidoglycan Synthesis in Helicobacter pylori and Escherichia coli.

Elhenawy W, Davis RM, Fero J, Salama NR, Feldman MF, Ruiz N.

PloS one. 2017; 12(1):e0170518.

PubMed [journal]
PMID:
28114371
PMCID:
PMC5256861

Research Summary

Helicobacter pylori infection is the major risk factor for stomach cancer, the third leading cancer killer worldwide. We study how this bacterium diversifies its genome and maintains helical cell shape, two adaptations that allow colonization in the unusual environment of the human stomach. We also explore the molecular cross talk between host and bacterium during chronic infection that drives disease.