student

Andrea Lim

andlim@uw.edu

Fred Hutchinson Cancer Research Institute, 

Public Health Sciences/Human Biology

Cancer Biology (Area Director)

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Entry Quarter: Autumn 2014

Research Summary

I study how the lymph node microenvironment regulates disseminated tumor cell (DTC) dormancy. DTCs are thought to initiate metastasis, the spread of cancer throughout the body. In order to survive in their new environments, DTCs can enter dormancy, a state characterized by reversible cell cycle arrest, immune evasion, and chemoresistance. The microenvironment of metastatic tissues has been implicated in regulating dormancy and reawakening. My project focuses on characterizing components of the lymph node microenvironment (cells, soluble factors, ECM proteins, etc.) that may impact DTC behavior.