CONJ 532: Signal Transduction: from the cell membrane to the nucleus
Cellular regulation at the molecular level is a fundamental tenet of all biomedical sciences. This course is a graduate level introduction to the foundations of cell signaling and how it pertains to disease. Topics this year will focus on the molecular mechanisms of cell signaling from the plasma membrane to the nucleus, systems analysis of covalent modifications (phosphorylation and ubiquitination), how chemical signals are transmitted through macromolecular complexes and signal transduction therapies. The class will use a combination of lecture, literature review, and in-class discussion and clinical case reports to conduct a molecular exploration of the cell. The course requires students to have taken undergraduate chemistry and biochemistry. Active participation in lectures and discussion are strongly encouraged.