MCB 522: The Developmental Basis of Human Disease

Description

Rapid advances in human genetics have identified a host of new genes associated with rare human genetic disorders. In many cases, the functions of these genes have already been elucidated by developmental and cell biologists working in non-human model systems. This ten-week course will explore the intimate relationship between developmental biology and human disease, including both inherited genetic disorders and cancer. Each week we will choose a different human disorder whose underlying genetic cause has been discovered. We will then discuss how the causal gene or genetic pathway controls normal animal development. The second meeting of each week will be an opportunity for students to present papers from the literature to uncover specific mechanistic links between normal developmental gene functions and disease. Offered in the fall of odd-numbered years.

Details

Instructor:

Cecilia Moens

Credits:

3.0

Quarter:

Autumn

Weeks:

1-10

Location:

Fred Hutch

Time:

T Th, 1-3:00pm

Foundational For:

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  • Developmental Biology, Stem Cells & Aging

Elective For:

  • Cancer Biology
  • Cell Signaling & Cell/Environment Interactions
  • Developmental Biology, Stem Cells & Aging
  • Genetics, Genomics & Evolution
  • Neuroscience

Course Attributes:

  • Lecture
  • Literature Review