The acquisition of cell motility and invasiveness is the hallmark of metastatic cancer. Cancer cells migrate using the same fundamental mechanisms as normal cells do when they migrate during development to form tissues and organs. This course explores mechanisms of cell migration, from the basic subcellular events that generate and stabilize cellular protrusions and generate force to the cell-contact mediated and diffusible cues that orient migration migration in vivo. In the final week of this five-week course we will discuss mechanisms of cancer cell migration and the role of the tumor microenvironment in metastasis. Each week will consist of one lecture and one student-led discussion of papers from the current literature. Offered in the fall of even-numbered years.
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