Cecilia Moens
cmoens@fredhutch.orgFred Hutch,
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging (Area Director)
Neuroscience
Nervous system development in zebrafish
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis.
Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J.
Dev Cell. 2018 Jun 18; 6(45)738-752.e6
Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum.
Kidwell CU, Su CY, Hibi M, Moens CB.
Dev Biol. 2018 Jun 1; 1(438)44-56
Barsh GR, Isabella AJ, Moens CB.
Curr Biol. 2017 Dec 18; 24(27)3812-3825.e3
Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo.
Roh-Johnson M, Shah AN, Stonick JA, Poudel KR, Kargl J, Yang GH, di Martino J, Hernandez RE, Gast CE, Zarour LR, Antoku S, Houghton AM, Bravo-Cordero JJ, Wong MH, Condeelis J, Moens CB.
Dev Cell. 2017 Dec 4; 5(43)549-562.e6
Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish.
Raghupathy RK, Zhang X, Liu F, Alhasani RH, Biswas L, Akhtar S, Pan L, Moens CB, Li W, Liu M, Kennedy BN, Shu X.
Sci Rep. 2017 Dec 4; 1(7)16881
Guidelines for morpholino use in zebrafish.
Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, Ingham PW, Schulte-Merker S, Yelon D, Weinstein BM, Mullins MC, Wilson SW, Ramakrishnan L, Amacher SL, Neuhauss SCF, Meng A, Mochizuki N, Panula P, Moens CB.
PLoS Genet. 2017 Oct; 10(13)e1007000
A genetic basis for molecular asymmetry at vertebrate electrical synapses.
Miller AC, Whitebirch AC, Shah AN, Marsden KC, Granato M, O'Brien J, Moens CB.
Elife. 2017 May 22; (6)
Planar cell polarity in moving cells: think globally, act locally.
Davey CF, Moens CB.
Development. 2017 Jan 15; 2(144)187-200
MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.
Anderson S, Poudel KR, Roh-Johnson M, Brabletz T, Yu M, Borenstein-Auerbach N, Grady WN, Bai J, Moens CB, Eisenman RN, Conacci-Sorrell M.
Proc Natl Acad Sci U S A. 2016 Sep 13; 37(113)E5481-90
Regulation of Vegf signaling by natural and synthetic ligands.
Rossi A, Gauvrit S, Marass M, Pan L, Moens CB, Stainier DYR.
Blood. 2016 Nov 10; 19(128)2359-2366
Targeted candidate gene screens using CRISPR/Cas9 technology.
Shah AN, Moens CB, Miller AC.
Methods Cell Biol. 2016; (135)89-106
Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish.
Stawicki TM, Hernandez L, Esterberg R, Linbo T, Owens KN, Shah AN, Thapa N, Roberts B, Moens CB, Rubel EW, Raible DW.
G3 (Bethesda). 2016 Jul 7; 7(6)2225-35
Li-Villarreal N, Forbes MM, Loza AJ, Chen J, Ma T, Helde K, Moens CB, Shin J, Sawada A, Hindes AE, Dubrulle J, Schier AF, Longmore GD, Marlow FL, Solnica-Krezel L.
Development. 2016 May 15; 10(143)1832
Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration.
Berg RD, Levitte S, O'Sullivan MP, O'Leary SM, Cambier CJ, Cameron J, Takaki KK, Moens CB, Tobin DM, Keane J, Ramakrishnan L.
Cell. 2016 Mar 24; 1(165)139-152
Approaching Perfection: New Developments in Zebrafish Genome Engineering.
Shah AN, Moens CB.
Dev Cell. 2016 Mar 21; 6(36)595-6
Davey CF, Mathewson AW, Moens CB.
PLoS Genet. 2016 Mar; 3(12)e1005934
Bachmann-Gagescu R, Dona M, Hetterschijt L, Tonnaer E, Peters T, de Vrieze E, Mans DA, van Beersum SE, Phelps IG, Arts HH, Keunen JE, Ueffing M, Roepman R, Boldt K, Doherty D, Moens CB, Neuhauss SC, Kremer H, van Wijk E.
PLoS Genet. 2015 Oct; 10(11)e1005575
Li-Villarreal N, Forbes MM, Loza AJ, Chen J, Ma T, Helde K, Moens CB, Shin J, Sawada A, Hindes AE, Dubrulle J, Schier AF, Longmore GD, Marlow FL, Solnica-Krezel L.
Development. 2015 Aug 1; 15(142)2704-18
Rapid Reverse Genetic Screening Using CRISPR in Zebrafish.
Shah AN, Davey CF, Whitebirch AC, Miller AC, Moens CB.
Zebrafish. 2016 Apr; 2(13)152-3
Pan L, Shah AN, Phelps IG, Doherty D, Johnson EA, Moens CB.
BMC Genomics. 2015 Feb 14; (16)83
Rapid reverse genetic screening using CRISPR in zebrafish.
Shah AN, Davey CF, Whitebirch AC, Miller AC, Moens CB.
Nat Methods. 2015 Jun; 6(12)535-40
Neurobeachin is required postsynaptically for electrical and chemical synapse formation.
Miller AC, Voelker LH, Shah AN, Moens CB.
Curr Biol. 2015 Jan 5; 1(25)16-28
Blasky AJ, Pan L, Moens CB, Appel B.
Dev Dyn. 2014 Dec; 12(243)1511-23
Distinct Notch signaling outputs pattern the developing arterial system.
Quillien A, Moore JC, Shin M, Siekmann AF, Smith T, Pan L, Moens CB, Parsons MJ, Lawson ND.
Development. 2014 Apr; 7(141)1544-52
Zigman M, Laumann-Lipp N, Titus T, Postlethwait J, Moens CB.
Development. 2014 Feb; 3(141)639-49
Notch3 establishes brain vascular integrity by regulating pericyte number.
Wang Y, Pan L, Moens CB, Appel B.
Development. 2014 Jan; 2(141)307-17
Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton.
DeLaurier A, Huycke TR, Nichols JT, Swartz ME, Larsen A, Walker C, Dowd J, Pan L, Moens CB, Kimmel CB.
Dev Biol. 2014 Jan 15; 2(385)189-99
Cerebellar development in the absence of Gbx function in zebrafish.
Su CY, Kemp HA, Moens CB.
Dev Biol. 2014 Feb 1; 1(386)181-90
Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling.
Lenkowski JR, Qin Z, Sifuentes CJ, Thummel R, Soto CM, Moens CB, Raymond PA.
Glia. 2013 Oct; 10(61)1687-97
The first mecp2-null zebrafish model shows altered motor behaviors.
Pietri T, Roman AC, Guyon N, Romano SA, Washbourne P, Moens CB, de Polavieja GG, Sumbre G.
Front Neural Circuits. 2013; (7)118
Alunni A, Krecsmarik M, Bosco A, Galant S, Pan L, Moens CB, Bally-Cuif L.
Development. 2013 Aug; 16(140)3335-47
barx1 represses joints and promotes cartilage in the craniofacial skeleton.
Nichols JT, Pan L, Moens CB, Kimmel CB.
Development. 2013 Jul; 13(140)2765-75
Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish.
Hewamadduma CA, Grierson AJ, Ma TP, Pan L, Moens CB, Ingham PW, Ramesh T, Shaw PJ.
Hum Mol Genet. 2013 Jun 15; 12(22)2376-86
Wnt-dependent epithelial transitions drive pharyngeal pouch formation.
Choe CP, Collazo A, Trinh le A, Pan L, Moens CB, Crump JG.
Dev Cell. 2013 Feb 11; 3(24)296-309
RNA-seq-based mapping and candidate identification of mutations from forward genetic screens.
Miller AC, Obholzer ND, Shah AN, Megason SG, Moens CB.
Genome Res. 2013 Apr; 4(23)679-86
Fior R, Maxwell AA, Ma TP, Vezzaro A, Moens CB, Amacher SL, Lewis J, Saúde L.
Development. 2012 Dec; 24(139)4656-65
Hinits Y, Pan L, Walker C, Dowd J, Moens CB, Hughes SM.
Dev Biol. 2012 Sep 15; 2(369)199-210
Sox9b is a key regulator of pancreaticobiliary ductal system development.
Delous M, Yin C, Shin D, Ninov N, Debrito Carten J, Pan L, Ma TP, Farber SA, Moens CB, Stainier DY.
PLoS Genet. 2012; 6(8)e1002754
Manfroid I, Ghaye A, Naye F, Detry N, Palm S, Pan L, Ma TP, Huang W, Rovira M, Martial JA, Parsons MJ, Moens CB, Voz ML, Peers B.
Dev Biol. 2012 Jun 15; 2(366)268-78
Differential regulation of epiboly initiation and progression by zebrafish Eomesodermin A.
Du S, Draper BW, Mione M, Moens CB, Bruce A.
Dev Biol. 2012 Feb 1; 1(362)11-23
Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b.
Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND, Mostov KE, Moens CB, Stainier DY.
Dev Biol. 2012 Jan 1; 1(361)68-78
De Rienzo G, Bishop JA, Mao Y, Pan L, Ma TP, Moens CB, Tsai LH, Sive H.
FASEB J. 2011 Dec; 12(25)4184-97
Bachmann-Gagescu R, Phelps IG, Stearns G, Link BA, Brockerhoff SE, Moens CB, Doherty D.
Hum Mol Genet. 2011 Oct 15; 20(20)4041-55
Hinits Y, Williams VC, Sweetman D, Donn TM, Ma TP, Moens CB, Hughes SM.
Dev Biol. 2011 Oct 1; 1(358)102-12
A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration.
Banerjee S, Gordon L, Donn TM, Berti C, Moens CB, Burden SJ, Granato M.
Development. 2011 Aug; 15(138)3287-96
Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish.
Huang HY, Houwing S, Kaaij LJ, Meppelink A, Redl S, Gauci S, Vos H, Draper BW, Moens CB, Burgering BM, Ladurner P, Krijgsveld J, Berezikov E, Ketting RF.
EMBO J. 2011 Jul 8; 16(30)3298-308
Asymmetric inhibition of Ulk2 causes left-right differences in habenular neuropil formation.
Taylor RW, Qi JY, Talaga AK, Ma TP, Pan L, Bartholomew CR, Klionsky DJ, Moens CB, Gamse JT.
J Neurosci. 2011 Jul 6; 27(31)9869-78
Walsh GS, Grant PK, Morgan JA, Moens CB.
Development. 2011 Jul; 14(138)3033-42
Mapp OM, Walsh GS, Moens CB, Tada M, Prince VE.
Development. 2011 May; 10(138)2121-32
Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions.
Žigman M, Trinh le A, Fraser SE, Moens CB.
Curr Biol. 2011 Jan 11; 1(21)79-86
Grant PK, Moens CB.
Neural Dev. 2010 Mar 29; (5)9
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.
Tobin DM, Vary JC Jr, Ray JP, Walsh GS, Dunstan SJ, Bang ND, Hagge DA, Khadge S, King MC, Hawn TR, Moens CB, Ramakrishnan L.
Cell. 2010 Mar 5; 5(140)717-30
Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism.
Feng L, Hernandez RE, Waxman JS, Yelon D, Moens CB.
Dev Biol. 2010 Feb 1; 1(338)1-14
A G protein-coupled receptor is essential for Schwann cells to initiate myelination.
Monk KR, Naylor SG, Glenn TD, Mercurio S, Perlin JR, Dominguez C, Moens CB, Talbot WS.
Science. 2009 Sep 11; 5946(325)1402-5
Pbx acts with Hand2 in early myocardial differentiation.
Maves L, Tyler A, Moens CB, Tapscott SJ.
Dev Biol. 2009 Sep 15; 2(333)409-18
Zebrafish survival motor neuron mutants exhibit presynaptic neuromuscular junction defects.
Boon KL, Xiao S, McWhorter ML, Donn T, Wolf-Saxon E, Bohnsack MT, Moens CB, Beattie CE.
Hum Mol Genet. 2009 Oct 1; 19(18)3615-25
A high-throughput method for zebrafish sperm cryopreservation and in vitro fertilization.
Draper BW, Moens CB.
J Vis Exp. 2009 Jul 6; 29
Kemp HA, Cooke JE, Moens CB.
Dev Biol. 2009 Mar 15; 2(327)313-26
Reverse genetics in zebrafish by TILLING.
Moens CB, Donn TM, Wolf-Saxon ER, Ma TP.
Brief Funct Genomic Proteomic. 2008 Nov; 6(7)454-9
Gorden NT, Arts HH, Parisi MA, Coene KL, Letteboer SJ, van Beersum SE, Mans DA, Hikida A, Eckert M, Knutzen D, Alswaid AF, Ozyurek H, Dibooglu S, Otto EA, Liu Y, Davis EE, Hutter CM, Bammler TK, Farin FM, Dorschner M, Topçu M, Zackai EH, Rosenthal P, Owens KN, Katsanis N, Vincent JB, Hildebrandt F, Rubel EW, Raible DW, Knoers NV, Chance PF, Roepman R, Moens CB, Glass IA, Doherty D.
Am J Hum Genet. 2008 Nov; 5(83)559-71
Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation.
Maves L, Waskiewicz AJ, Paul B, Cao Y, Tyler A, Moens CB, Tapscott SJ.
Development. 2007 Sep; 18(134)3371-82
Pbx homeodomain proteins pattern both the zebrafish retina and tectum.
French CR, Erickson T, Callander D, Berry KM, Koss R, Hagey DW, Stout J, Wuennenberg-Stapleton K, Ngai J, Moens CB, Waskiewicz AJ.
BMC Dev Biol. 2007 Jul 16; (7)85
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.
Houwing S, Kamminga LM, Berezikov E, Cronembold D, Girard A, van den Elst H, Filippov DV, Blaser H, Raz E, Moens CB, Plasterk RH, Hannon GJ, Draper BW, Ketting RF.
Cell. 2007 Apr 6; 1(129)69-82
nanos1 is required to maintain oocyte production in adult zebrafish.
Draper BW, McCallum CM, Moens CB.
Dev Biol. 2007 May 15; 2(305)589-98
Neuropilin asymmetry mediates a left-right difference in habenular connectivity.
Kuan YS, Yu HH, Moens CB, Halpern ME.
Development. 2007 Mar; 5(134)857-65
Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development.
Hernandez RE, Putzke AP, Myers JP, Margaretha L, Moens CB.
Development. 2007 Jan; 1(134)177-87
Erickson T, Scholpp S, Brand M, Moens CB, Waskiewicz AJ.
Dev Biol. 2007 Jan 15; 2(301)504-17
Cooper KL, Armstrong J, Moens CB.
Dev Dyn. 2005 Nov; 3(234)651-8
Semaphorin signaling guides cranial neural crest cell migration in zebrafish.
Yu HH, Moens CB.
Dev Biol. 2005 Apr 15; 2(280)373-85
EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish.
Cooke JE, Kemp HA, Moens CB.
Curr Biol. 2005 Mar 29; 6(15)536-42
Draper BW, McCallum CM, Stout JL, Slade AJ, Moens CB.
Methods Cell Biol. 2004; (77)91-112
Hernandez RE, Rikhof HA, Bachmann R, Moens CB.
Development. 2004 Sep; 18(131)4511-20
Cloning and embryonic expression of zebrafish neuropilin genes.
Yu HH, Houart C, Moens CB.
Gene Expr Patterns. 2004 Jul; 4(4)371-8
Autonomous and nonautonomous functions for Hox/Pbx in branchiomotor neuron development.
Cooper KL, Leisenring WM, Moens CB.
Dev Biol. 2003 Jan 15; 2(253)200-13
Eliminating zebrafish pbx proteins reveals a hindbrain ground state.
Waskiewicz AJ, Rikhof HA, Moens CB.
Dev Cell. 2002 Nov; 5(3)723-33
Constructing the hindbrain: insights from the zebrafish.
Moens CB, Prince VE.
Dev Dyn. 2002 May; 1(224)1-17
Boundary formation in the hindbrain: Eph only it were simple...
Cooke JE, Moens CB.
Trends Neurosci. 2002 May; 5(25)260-7
Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning.
Waskiewicz AJ, Rikhof HA, Hernandez RE, Moens CB.
Development. 2001 Nov; 21(128)4139-51
Well developed: the SDB reaches 60. Society for Developmental Biology.
Moens CB
Trends Genet. 2001 Oct; 10(17)559-61
Zebrafish deadly seven functions in neurogenesis.
Gray M, Moens CB, Amacher SL, Eisen JS, Beattie CE.
Dev Biol. 2001 Sep 15; 2(237)306-23
Specification and morphogenesis of the zebrafish larval head skeleton.
Kimmel CB, Miller CT, Moens CB.
Dev Biol. 2001 May 15; 2(233)239-57
lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish.
Pöpperl H, Rikhof H, Chang H, Haffter P, Kimmel CB, Moens CB.
Mol Cell. 2000 Aug; 2(6)255-67
Prince VE, Moens CB, Kimmel CB, Ho RK.
Development. 1998 Feb; 3(125)393-406
Equivalence in the genetic control of hindbrain segmentation in fish and mouse.
Moens CB, Cordes SP, Giorgianni MW, Barsh GS, Kimmel CB.
Development. 1998 Feb; 3(125)381-91
Development of branchiomotor neurons in zebrafish.
Chandrasekhar A, Moens CB, Warren JT Jr, Kimmel CB, Kuwada JY.
Development. 1997 Jul; 13(124)2633-44
valentino: a zebrafish gene required for normal hindbrain segmentation.
Moens CB, Yan YL, Appel B, Force AG, Kimmel CB.
Development. 1996 Dec; 12(122)3981-90
Moens CB, Stanton BR, Parada LF, Rossant J.
Development. 1993 Oct; 2(119)485-99
A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung.
Moens CB, Auerbach AB, Conlon RA, Joyner AL, Rossant J.
Genes Dev. 1992 May; 5(6)691-704
Research Summary
The Moens lab studies the early development of the vertebrate brain, using the transparent zebrafish embryo as our in vivo model system. Our approaches combine genetics and in vivo imaging of neurons and neural progenitors in the process of neuroepithelial morphogenesis, neuronal migration and axogenesis with the goal of understanding how genes control the early events in the embryo that ultimately lead to the establishment of normal neural circuits.