faculty

David Sherman

david.sherman@cidresearch.org

Center for Infectious Disease Research, 

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Tuberculosis Systems Biology: Virulence And Dormancy

Faculty Contact Information

Building: 307 Westlake Phone: 206-256-7242 https://www.cidresearch.org/labs/sherman

Lab Information

Accepting Students For:

Rotation, Autumn
Rotation, Summer
Rotation, Winter
Permanent

Publications

Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection.

Drain PK, Bajema KL, Dowdy D, Dheda K, Naidoo K, Schumacher SG, Ma S, Meermeier E, Lewinsohn DM, Sherman DR.

Clinical microbiology reviews. 2018; 31(4).

PubMed [journal]
PMID:
30021818
PMCID:
PMC6148193

Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination.

Cohen SB, Gern BH, Delahaye JL, Adams KN, Plumlee CR, Winkler JK, Sherman DR, Gerner MY, Urdahl KB.

Cell host & microbe. 2018; 24(3):439-446.e4. NIHMSID: NIHMS1503296

PubMed [journal]
PMID:
30146391
PMCID:
PMC6152889

Bacterial Factors That Predict Relapse after Tuberculosis Therapy.

Colangeli R, Jedrey H, Kim S, Connell R, Ma S, Chippada Venkata UD, Chakravorty S, Gupta A, Sizemore EE, Diem L, Sherman DR, Okwera A, Dietze R, Boom WH, Johnson JL, Mac Kenzie WR, Alland D.

The New England journal of medicine. 2018; 379(9):823-833. NIHMSID: NIHMS1507282

PubMed [journal]
PMID:
30157391
PMCID:
PMC6317071

Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose.

Boot M, van Winden VJC, Sparrius M, van de Weerd R, Speer A, Ummels R, Rustad T, Sherman DR, Bitter W.

PLoS genetics. 2017; 13(12):e1007131.

PubMed [journal]
PMID:
29281637
PMCID:
PMC5760070

Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis.

Moguche AO, Musvosvi M, Penn-Nicholson A, Plumlee CR, Mearns H, Geldenhuys H, Smit E, Abrahams D, Rozot V, Dintwe O, Hoff ST, Kromann I, Ruhwald M, Bang P, Larson RP, Shafiani S, Ma S, Sherman DR, Sette A, Lindestam Arlehamn CS, McKinney DM, Maecker H, Hanekom WA, Hatherill M, Andersen P, Scriba TJ, Urdahl KB.

Cell host & microbe. 2017; 21(6):695-706.e5. NIHMSID: NIHMS881418

PubMed [journal]
PMID:
28618268
PMCID:
PMC5533182

Research Summary

With about 30% of the world’s population infected and 1.4 million deaths caused each year, Mycobacterium tuberculosis is the world’s deadliest bacterium. The Sherman laboratory studies the bacterial and host strategies that underpin this success. We use tools of systems biology such as transcriptomics, ChIP-seq and modeling to define the TB gene regulatory network under physiologically relevant conditions, and use the modeling in turn to produce testable hypotheses about novel regulatory circuits, genes and proteins of TB.