University of Washington,
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Molecular underpinnings of neurodegenerative disease
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Dr. Kraemer’s research group investigates the molecular causes of neurodegeneration in Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and related disorders of the nervous system. His lab utilizes C. elegans and mouse models for the tau pathology seen in Alzheimer’s disease and for the TDP-43 pathology seen in ALS to investigate disease mechanisms. Recent work has employed CRISPR/Cas9 genome engineering technology to develop new disease models and test hypotheses about molecular disease mechanisms.