faculty

Brian Kraemer

kraemerb@uw.edu
Research Professor

University of Washington

Psychiatry & Behavioral Sciences

Developmental Biology, Stem Cells & Aging

Genetics, Genomics & Evolution

Neuroscience

Molecular Mechanisms of Neurodegenerative Diseases

Faculty Contact Information

Building: VA PSHCS Room: Building 1, Room 711 Box: Box 358280 Phone: 206-277-1071 http://kraemerlab.uw.edu/

Research Summary

Dr. Kraemer’s research group investigates the molecular causes of neurodegeneration in Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and related disorders of the nervous system. His lab utilizes C. elegans and mouse models for the tau pathology seen in Alzheimer’s disease and for the TDP-43 pathology seen in ALS to investigate disease mechanisms. Recent work has employed CRISPR/Cas9 genome engineering technology to develop new disease models and test hypotheses about molecular disease mechanisms.

DEI Statement

As a mentor, I strive to tailor both the training experience and environment to meet the individual needs and learning objectives of each mentee with the goal of helping them to realize their full potential as a scientist and a scholar. Clearly each of us as scientists function as an individual with distinct preferences, personalities, abilities, strengths, and limitations impacted by our individual experiences, background, and education. To establish a tailored training environment for each trainee, I engage in an ongoing dialog with each member of my laboratory to balance personal development, academic achievement, and scientific progress. The diversity within my laboratory benefits all of us by contributing to its scientific productivity and effectiveness as a training environment. My ultimate mentoring objective is to support my mentees on their journey as they develop as scientist to achieve their academic and professional goals.

Training Summary

Anti-Racism Training (Neuroscience Training Program) – 2021

Mentor Training (CIMER, MCB sponsored workshop) – 2019

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_639156b7140c5477e5470122&retmode=json
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Publications

The following publications were retrieved from PubMed:

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans.

Latimer CS, Stair JG, Hincks JC, Currey HN, Bird TD, Keene CD, Kraemer BC, Liachko NF.

Dis Model Mech. 2022 Apr 1; 4(15)

Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration.

Kow RL, Black AH, Saxton AD, Liachko NF, Kraemer BC.

Geroscience. 2022 Apr; 2(44)747-761

Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease.

McMillan PJ, Strovas TJ, Baum M, Mitchell BK, Eck RJ, Hendricks N, Wheeler JM, Latimer CS, Keene CD, Kraemer BC.

Acta Neuropathol Commun. 2021 Jun 29; 1(9)117

Regulation of TDP-43 phosphorylation in aging and disease.

Eck RJ, Kraemer BC, Liachko NF.

Geroscience. 2021 Aug; 4(43)1605-1614



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Lab Information

Location: VA PSHCS
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Room: S182C
Box: 358280
Phone: 206-277-1071
Alt Phone: 2062771071
http://kraemerlab.uw.edu/