faculty

Rosana Risques

rrisques@uw.edu

University of Washington, 

Cancer Biology

Genetics, Genomics & Evolution

early cancer detection

Faculty Contact Information

Building: HSB Room: E506 Box: 357470 Phone: 206-616-4976 http://depts.washington.edu/risques/

Lab Information

Location: University of Washington Building: HSB Room: E506 Box: 357470 Phone: 206-221-8255 http://depts.washington.edu/risques/

Accepting Students For:

Rotation, Spring
Rotation, Summer
Rotation, Winter

Publications

Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer.

Baker KT, Nachmanson D, Kumar S, Emond MJ, Ussakli C, Brentnall TA, Kennedy SR, Risques RA.

Molecular cancer research : MCR. 2019; 17(2):488-498. NIHMSID: NIHMS1014847

PubMed [journal]
PMID:
30446624
PMCID:
PMC6481604

Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS).

Nachmanson D, Lian S, Schmidt EK, Hipp MJ, Baker KT, Zhang Y, Tretiakova M, Loubet-Senear K, Kohrn BF, Salk JJ, Kennedy SR, Risques RA.

Genome research. 2018; 28(10):1589-1599.

PubMed [journal]
PMID:
30232196
PMCID:
PMC6169890

Seshat: A Web service for accurate annotation, validation, and analysis of TP53 variants generated by conventional and next-generation sequencing.

Tikkanen T, Leroy B, Fournier JL, Risques RA, Malcikova J, Soussi T.

Human mutation. 2018; 39(7):925-933.

PubMed [journal]
PMID:
29696732

All's well that ends well: why large species have short telomeres.

Risques RA, Promislow DEL.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2018; 373(1741).

PubMed [journal]
PMID:
29335372
PMCID:
PMC5784068

Precancer in ulcerative colitis: the role of the field effect and its clinical implications.

Baker KT, Salk JJ, Brentnall TA, Risques RA.

Carcinogenesis. 2018; 39(1):11-20.

PubMed [journal]
PMID:
29087436
PMCID:
PMC6248676

Research Summary

Research at the Risques Lab focuses on the development of biomarkers for early detection and prediction of cancer. We are especially interested in alterations that link cancer and aging including telomere shortening, mitochondrial dysfunction, and mutational load. Our main projects involve the application of novel molecular technologies, including NGS, to early cancer detection in the context of ulcerative colitis, an inflammatory bowel disease that predisposes to colorectal cancer. We also work on early detection of ovarian cancer by ultra-deep sequencing of liquid biopsies.