faculty

David Fredricks

dfredric@uw.edu
Member

Fred Hutch

Vaccine and Infections Disease Institute

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

The human microbiome

Faculty Contact Information

Research Summary

We study human associated microbial communities, including their composition, structure, dynamics and function. Our goal is to advance our understanding of how microbial populations in humans influence health and susceptibility to disease. Ongoing projects in the lab focus on the gut microbiome in patients with cancer and its connection with graft versus host disease and other outcomes in transplant recipients. We also study how the genital tract microbiota influences HIV infection, other sexually transmitted infections, preterm birth, and urethritis in men.

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Publications

The following publications were retrieved from PubMed:

Resolution of Symptoms and Resumption of Sex After Diagnosis of Nongonococcal Urethritis Among Men Who Have Sex With Men.

Chambers LC, Hughes JP, Glick SN, Morgan JL, Lowens MS, Robinson TS, Romano SS, Leipertz GL, Jensen JS, Khosropour CM, Fredricks DN, Golden MR, Manhart LE.

Sex Transm Dis. 2019 Oct; 10(46)676-682

Tenofovir disoproxil fumarate intravaginal ring for HIV pre-exposure prophylaxis in sexually active women: a phase 1, single-blind, randomised, controlled trial.

Keller MJ, Wood L, Billingsley JM, Ray LL, Goymer J, Sinclair S, McGinn AP, Marzinke MA, Frank B, Srinivasan S, Liu C, Atrio JM, Espinoza L, Mugo N, Spiegel HML, Anderson PL, Fredricks DN, Hendrix CW, Marrazzo J, Bosinger SE, Herold BC.

Lancet HIV. 2019 Aug; 8(6)e498-e508

Specific vaginal bacteria are associated with increased risk of Trichomonas vaginalis acquisition in women.

Jarrett OD, Srinivasan S, Richardson BA, Fiedler T, Wallis JM, Kinuthia J, Jaoko W, Mandaliya K, Fredricks DN, McClelland RS.

J Infect Dis. 2019 Jul 9;

Associations between vaginal bacteria implicated in HIV acquisition risk and proinflammatory cytokines and chemokines.

Sabo MC, Lehman DA, Wang B, Richardson BA, Srinivasan S, Osborn L, Matemo D, Kinuthia J, Fiedler TL, Munch MM, Drake AL, Fredricks DN, Overbaugh J, John-Stewart G, McClelland RS, Graham SM.

Sex Transm Infect. 2019 Jun 13;

The gut microbiota and graft-versus-host disease.

Fredricks DN

J Clin Invest. 2019 May 1; 5(129)1808-1817

Accepting Students For:

Rotation, Spring
Rotation, Winter
Permanent

Lab Information

Location: Fred Hutch
Building: Eastlake
Box: E4-100
http://research.fhcrc.org/fredricks/en.html