University of Washington
Biophysical and Structural Biology
Cell Signaling & Cell/Environment Interactions
Ion channels, fluorescence methods, pain
Faculty Contact Information
The Gordon lab is interested in the way proteins work as molecular machines. How does a single protein molecule measure many environmental factors and do a calculation based on those factors? The sensory transduction ion channels in the TRP family have multiple sensing domains, including for temperature, noxious chemicals, and lipid signals. The single output of TRP channels, their open probability, is determined by the energetics by which each sensing domain is coupled to the channel pore. In the Gordon lab, we use state-of-the-art biophysical approaches to understanding TRP channels.