William M. Gradywgrady@fredhutch.org
Cell Signaling & Cell/Environment Interactions
Gene Expression, Cell Cycle & Chromosome Biology
Molecular and cell biology of gastrointestinal cancer and Cancer epigenetics
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The Grady lab studies the molecular pathogenesis of gastrointestinal cancer, with areas of focus on the the study of mutations and epigenetic alterations in driving cancer formation and on the role of cancer epigenetics in the initiation and progression of tumors. We use a variety of cutting-edge approaches (organoid cultures, methylation arrays, droplet digital PCR, next-generation sequencing, bisulfite sequencing, organoid cultures, CRISPR-Cas9, etc)in different model systems and primary tissues in order to discover the functional role of molecular alterations in the tumorigenesis process.