Toshio Tsukiyama

Research Summary

In eukaryotic cells, DNA is packaged into chromatin, which allows compact storage of the genome, but limits the access of DNA binding proteins to their targets. As a result, chromatin structure affects virtually all DNA-dependent processes and chromatin regulators are frequently mutated in cancer. However, how chromatin regulation affects cell division and cell-cycle is not well unserstood. We are especially interested in cell quiescence, and are investigating how chromatin regulation affects the entry, maintenance and exit from quiescence.

DEI Statement

In the Tsukiyama lab, we value a culture of diversity, equity and inclusion. We welcome everybody to the lab irrespective of cultural, ethnic and racial identity, religion, age, sexual identity and orientation, socioeconomic status, disability, or veteran status.

We believe diversity strengthens our society, lab environment, and science. We are committed to celebrate our differences.

Training Summary

Our goal is to make every member of the lab a better scientist through training. We have weekly data club, journal club, one on one meetings, monthly chromatin club, Tuesday seminar series and Friday Night Talks to facilitate training. In the lab, trainees have opportunities to learn biology of cell quiescence, chromatin biology, transcription, DNA damage response and DNA replication. In terms of techniques, people are trained in molecular genetics, genomics, bioinformatics and biochemistry. In addition, we train people in writing and presentation styles.